3qb1: Difference between revisions

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[[Image:3qb1.png|left|200px]]
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{{STRUCTURE_3qb1|  PDB=3qb1  |  SCENE=  }}  
{{STRUCTURE_3qb1|  PDB=3qb1  |  SCENE=  }}  
===Interleukin-2 mutant D10===
===Interleukin-2 mutant D10===
{{ABSTRACT_PUBMED_22446627}}


==Disease==
[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_22446627}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
(as it appears on PubMed at http://www.pubmed.gov), where 22446627 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22446627}}


==About this Structure==
==About this Structure==
[[3qb1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QB1 OCA].  
[[3qb1]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QB1 OCA].  
==See Also==
*[[Interleukin|Interleukin]]


==Reference==
==Reference==
<ref group="xtra">PMID:022446627</ref><references group="xtra"/>
<ref group="xtra">PMID:022446627</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bates, D L.]]
[[Category: Bates, D L.]]

Revision as of 19:34, 24 March 2013

Template:STRUCTURE 3qb1

Interleukin-2 mutant D10

Template:ABSTRACT PUBMED 22446627

Disease

[IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

Function

[IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

About this Structure

3qb1 is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Levin AM, Bates DL, Ring AM, Krieg C, Lin JT, Su L, Moraga I, Raeber ME, Bowman GR, Novick P, Pande VS, Fathman CG, Boyman O, Garcia KC. Exploiting a natural conformational switch to engineer an interleukin-2 'superkine' Nature. 2012 Mar 25. doi: 10.1038/nature10975. PMID:22446627 doi:10.1038/nature10975

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