3ara: Difference between revisions

Revision as of 04:56, 26 July 2012

3ara is a 3 chain structure of Deoxyuridine 5'-triphosphate nucleotidohydrolase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Miyakoshi H, Miyahara S, Yokogawa T, Chong KT, Taguchi J, Endoh K, Yano W, Wakasa T, Ueno H, Takao Y, Nomura M, Shuto S, Nagasawa H, Fukuoka M. Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors. J Med Chem. 2012 Apr 12;55(7):2960-9. Epub 2012 Mar 26. PMID:22404301 doi:10.1021/jm201627n

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 [[Image:3ara.png|left|200px]]
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 ===Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors===
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