3dtc: Difference between revisions

Revision as of 00:16, 27 July 2012

3dtc is a 1 chain structure of Mitogen-activated protein kinase kinase kinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Hudkins RL, Diebold JL, Tao M, Josef KA, Park CH, Angeles TS, Aimone LD, Husten J, Ator MA, Meyer SL, Holskin BP, Durkin JT, Fedorov AA, Fedorov EV, Almo SC, Mathiasen JR, Bozyczko-Coyne D, Saporito MS, Scott RW, Mallamo JP. Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models. J Med Chem. 2008 Sep 25;51(18):5680-9. Epub 2008 Aug 21. PMID:18714982 doi:10.1021/jm8005838

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 [[Image:3dtc.png|left|200px]]
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 ===Crystal structure of mixed-lineage kinase MLK1 complexed with compound 16===
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