Function
Mitogen-activated protein kinase kinase kinase or DLK (MAP3K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP3K is part of the MAPK cascade which consists also of MAPK and MAP2K which are activated by phosphorylation. MAP3K activates MAP2K[1].
- MAP3K1 regulates cell migration and contributes to pro-survival signaling[2].
- MAP3K10 has a role in the tumorugenesis of pancreatic ductal adenocarcinoma[3].
- MAP3K14 is a regulator of enforced viral replication in the spleen[4].
Disease
MAP3K1 mutations are observed in various cancer types and in particular in luminal beast cancer[5].
3D Structures of Mitogen-activated protein kinase kinase kinase
Mitogen-activated protein kinase kinase kinase 3D structures
References
- ↑ Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative. J Biol Chem. 1997 Jan 31;272(5):2668-74. PMID:9006902
- ↑ Pham TT, Angus SP, Johnson GL. MAP3K1: Genomic Alterations in Cancer and Function in Promoting Cell Survival or Apoptosis. Genes Cancer. 2013 Nov;4(11-12):419-26. PMID:24386504 doi:10.1177/1947601913513950
- ↑ An Y, Cai B, Chen J, Lv N, Yao J, Xue X, Tu M, Tang D, Wei J, Jiang K, Wu J, Li Q, Gao W, Miao Y. MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2. Cancer Lett. 2013 Feb 28;329(2):228-35. PMID:23178452 doi:10.1016/j.canlet.2012.11.005
- ↑ Hamdan TA, Bhat H, Cham LB, Adomati T, Lang J, Li F, Murtaza A, Hardt C, Lang PA, Duhan V, Lang KS. Map3k14 as a Regulator of Innate and Adaptive Immune Response during Acute Viral Infection. Pathogens. 2020 Feb 4;9(2):96. PMID:32033109 doi:10.3390/pathogens9020096
- ↑ Santen RJ, Song RX, McPherson R, Kumar R, Adam L, Jeng MH, Yue W. The role of mitogen-activated protein (MAP) kinase in breast cancer. J Steroid Biochem Mol Biol. 2002 Feb;80(2):239-56. PMID:11897507
