2nvk: Difference between revisions

Revision as of 07:05, 27 July 2012

Ligands:

FAD, NAP

Gene:

Trxr-1 (Drosophila melanogaster)

Activity:

Thioredoxin-disulfide reductase, with EC number 1.8.1.9

Structural annotation:
Resources:	InterPro : Ipr001327, Ipr000815, Ipr012999, Ipr004099, Ipr013027, Ipr006338, Ipr001100 Pfam : PF02852, PF00070, PF07992 UniProt : P91938

Functional annotation:
Cellular component:	mitochondrion cytoplasm
Biological process:	thioredoxin pathway cell redox homeostasis electron transport determination of adult life span
Molecular function:	oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor thioredoxin-disulfide reductase activity FAD binding oxidoreductase activity antioxidant activity protein binding NADP binding glutathione-disulfide reductase activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

2nvk is a 1 chain structure of Thioredoxin Reductase with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Eckenroth BE, Rould MA, Hondal RJ, Everse SJ. Structural and biochemical studies reveal differences in the catalytic mechanisms of mammalian and Drosophila melanogaster thioredoxin reductases. Biochemistry. 2007 Apr 24;46(16):4694-705. Epub 2007 Mar 27. PMID:17385893 doi:10.1021/bi602394p

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