1py2: Difference between revisions
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{{STRUCTURE_1py2| PDB=1py2 | SCENE= }} | {{STRUCTURE_1py2| PDB=1py2 | SCENE= }} | ||
===Structure of a 60 nM Small Molecule Bound to a Hot Spot on IL-2=== | |||
{{ABSTRACT_PUBMED_14664558}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN]] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. | |||
==About this Structure== | ==About this Structure== | ||
| Line 14: | Line 16: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:014664558</ref><references group="xtra"/> | <ref group="xtra">PMID:014664558</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Randal, M.]] | [[Category: Randal, M.]] | ||
Revision as of 17:39, 24 March 2013
Structure of a 60 nM Small Molecule Bound to a Hot Spot on IL-2
Template:ABSTRACT PUBMED 14664558
Disease
[IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
Function
[IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
About this Structure
1py2 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Thanos CD, Randal M, Wells JA. Potent small-molecule binding to a dynamic hot spot on IL-2. J Am Chem Soc. 2003 Dec 17;125(50):15280-1. PMID:14664558 doi:10.1021/ja0382617
