2x4t: Difference between revisions
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{{STRUCTURE_2x4t| PDB=2x4t | SCENE= }} | {{STRUCTURE_2x4t| PDB=2x4t | SCENE= }} | ||
===CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO A PEIODATE-CLEAVABLE PEPTIDE=== | ===CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO A PEIODATE-CLEAVABLE PEPTIDE=== | ||
{{ABSTRACT_PUBMED_19655751}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/PP65_HCMVA PP65_HCMVA]] Counteracts the host antiviral immune response when activated and phosphorylated, by preventing IRF3 from entering the nucleus. Also participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes.<ref>PMID:15452220</ref><ref>PMID:20504932</ref> | |||
==About this Structure== | ==About this Structure== | ||
| Line 15: | Line 14: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:019655751</ref><ref group="xtra">PMID:019655750</ref><references group="xtra"/> | <ref group="xtra">PMID:019655751</ref><ref group="xtra">PMID:019655750</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Celie, P H.N.]] | [[Category: Celie, P H.N.]] | ||
Revision as of 21:55, 24 March 2013
CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO A PEIODATE-CLEAVABLE PEPTIDE
Template:ABSTRACT PUBMED 19655751
Function
[1A02_HUMAN] Involved in the presentation of foreign antigens to the immune system. [PP65_HCMVA] Counteracts the host antiviral immune response when activated and phosphorylated, by preventing IRF3 from entering the nucleus. Also participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes.[1][2]
About this Structure
2x4t is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Rodenko B, Toebes M, Celie PH, Perrakis A, Schumacher TN, Ovaa H. Class I major histocompatibility complexes loaded by a periodate trigger. J Am Chem Soc. 2009 Sep 2;131(34):12305-13. PMID:19655751 doi:10.1021/ja9037565
- Celie PH, Toebes M, Rodenko B, Ovaa H, Perrakis A, Schumacher TN. UV-induced ligand exchange in MHC class I protein crystals. J Am Chem Soc. 2009 Sep 2;131(34):12298-304. PMID:19655750 doi:10.1021/ja9037559
- ↑ Abate DA, Watanabe S, Mocarski ES. Major human cytomegalovirus structural protein pp65 (ppUL83) prevents interferon response factor 3 activation in the interferon response. J Virol. 2004 Oct;78(20):10995-1006. PMID:15452220 doi:10.1128/JVI.78.20.10995-11006.2004
- ↑ Cristea IM, Moorman NJ, Terhune SS, Cuevas CD, O'Keefe ES, Rout MP, Chait BT, Shenk T. Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein. J Virol. 2010 Aug;84(15):7803-14. doi: 10.1128/JVI.00139-10. Epub 2010 May 26. PMID:20504932 doi:10.1128/JVI.00139-10
