1uk1: Difference between revisions

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[[Image:1uk1.gif|left|200px]]<br /><applet load="1uk1" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1uk1.gif|left|200px]]
caption="1uk1, resolution 3.&Aring;" />
 
'''Crystal structure of human poly(ADP-ribose) polymerase complexed with a potent inhibitor'''<br />
{{Structure
|PDB= 1uk1 |SIZE=350|CAPTION= <scene name='initialview01'>1uk1</scene>, resolution 3.&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=FRQ:5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE'>FRQ</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30]
|GENE=
}}
 
'''Crystal structure of human poly(ADP-ribose) polymerase complexed with a potent inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1UK1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FRQ:'>FRQ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UK1 OCA].  
1UK1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UK1 OCA].  


==Reference==
==Reference==
Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase., Hattori K, Kido Y, Yamamoto H, Ishida J, Kamijo K, Murano K, Ohkubo M, Kinoshita T, Iwashita A, Mihara K, Yamazaki S, Matsuoka N, Teramura Y, Miyake H, J Med Chem. 2004 Aug 12;47(17):4151-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15293985 15293985]
Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase., Hattori K, Kido Y, Yamamoto H, Ishida J, Kamijo K, Murano K, Ohkubo M, Kinoshita T, Iwashita A, Mihara K, Yamazaki S, Matsuoka N, Teramura Y, Miyake H, J Med Chem. 2004 Aug 12;47(17):4151-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15293985 15293985]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: NAD(+) ADP-ribosyltransferase]]
[[Category: NAD(+) ADP-ribosyltransferase]]
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[[Category: protein-inhibitor complex]]
[[Category: protein-inhibitor complex]]


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