2w0s: Difference between revisions
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{{STRUCTURE_2w0s| PDB=2w0s | SCENE= }} | {{STRUCTURE_2w0s| PDB=2w0s | SCENE= }} | ||
===Crystal structure of vaccinia virus thymidylate kinase bound to brivudin-5'-monophosphate=== | |||
{{ABSTRACT_PUBMED_18971333}} | |||
== | ==Function== | ||
[[http://www.uniprot.org/uniprot/KTHY_VACCC KTHY_VACCC]] Poxvirus TMP kinase is able to phosphorylate dTMP, dUMP and also dGMP from any purine and pyrimidine nucleoside triphosphate. The large substrate specificity is explained by the presence of a canal connecting the edge of the dimer interface to the TMP base binding pocket, canal not found in the human homolog (By similarity). | |||
==About this Structure== | |||
[[2w0s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccc Vaccc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0S OCA]. | |||
== | ==See Also== | ||
[[ | *[[Thymidylate kinase|Thymidylate kinase]] | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018971333</ref><references group="xtra"/> | <ref group="xtra">PMID:018971333</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Vaccc]] | ||
[[Category: DTMP kinase]] | [[Category: DTMP kinase]] | ||
[[Category: Agrofoglio, L A.]] | [[Category: Agrofoglio, L A.]] | ||
Revision as of 12:14, 20 November 2013
Crystal structure of vaccinia virus thymidylate kinase bound to brivudin-5'-monophosphate
Template:ABSTRACT PUBMED 18971333
Function
[KTHY_VACCC] Poxvirus TMP kinase is able to phosphorylate dTMP, dUMP and also dGMP from any purine and pyrimidine nucleoside triphosphate. The large substrate specificity is explained by the presence of a canal connecting the edge of the dimer interface to the TMP base binding pocket, canal not found in the human homolog (By similarity).
About this Structure
2w0s is a 2 chain structure with sequence from Vaccc. Full crystallographic information is available from OCA.
See Also
Reference
- Caillat C, Topalis D, Agrofoglio LA, Pochet S, Balzarini J, Deville-Bonne D, Meyer P. Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16900-5. Epub 2008 Oct 29. PMID:18971333
