2r42: Difference between revisions
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{{STRUCTURE_2r42| PDB=2r42 | SCENE= }} | {{STRUCTURE_2r42| PDB=2r42 | SCENE= }} | ||
===The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism=== | |||
{{ABSTRACT_PUBMED_18302342}} | |||
== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/KIME_RAT KIME_RAT]] Note=Mutation in the mevalonate kinase gene causes mevalonicaciduria. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/KIME_RAT KIME_RAT]] May be a regulatory site in cholesterol biosynthetic pathway. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:018302342</ref><references group="xtra"/> | <ref group="xtra">PMID:018302342</ref><references group="xtra"/><references/> | ||
[[Category: Mevalonate kinase]] | [[Category: Mevalonate kinase]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
Revision as of 00:56, 25 March 2013
The Biochemical and Structural Basis for feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism
Template:ABSTRACT PUBMED 18302342
Disease
[KIME_RAT] Note=Mutation in the mevalonate kinase gene causes mevalonicaciduria.
Function
[KIME_RAT] May be a regulatory site in cholesterol biosynthetic pathway.
About this Structure
2r42 is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Fu Z, Voynova NE, Herdendorf TJ, Miziorko HM, Kim JJ. Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism. Biochemistry. 2008 Mar 25;47(12):3715-24. Epub 2008 Feb 27. PMID:18302342 doi:10.1021/bi7024386
