2hak: Difference between revisions
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{{STRUCTURE_2hak| PDB=2hak | SCENE= }} | {{STRUCTURE_2hak| PDB=2hak | SCENE= }} | ||
===Catalytic and ubiqutin-associated domains of MARK1/PAR-1=== | |||
{{ABSTRACT_PUBMED_16803889}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Note=Genetic variations in MARK1 may be associated with susceptibility to autism. MARK1 is overexpressed in the prefrontal cortex of patients with autism and causes changes in the function of cortical dendrites. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MARK1_HUMAN MARK1_HUMAN]] Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).<ref>PMID:11433294</ref><ref>PMID:17573348</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:016803889</ref><ref group="xtra">PMID:016472737</ref><references group="xtra"/> | <ref group="xtra">PMID:016803889</ref><ref group="xtra">PMID:016472737</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
