4joi: Difference between revisions
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{{STRUCTURE_4joi| PDB=4joi | SCENE= }} | |||
===Crystal structure of the human telomeric Stn1-Ten1 complex=== | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/STN1_HUMAN STN1_HUMAN]] Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.<ref>PMID:19854130</ref> <ref>PMID:19648609</ref> [[http://www.uniprot.org/uniprot/TEN1L_HUMAN TEN1L_HUMAN]] Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. | |||
==About this Structure== | |||
[[4joi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JOI OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Bryan, C.]] | |||
[[Category: Harkisheimer, M.]] | |||
[[Category: Rice, C.]] | |||
[[Category: Schultz, D.]] | |||
[[Category: Skordalakes, E.]] | |||
[[Category: Dna binding protein]] | |||
[[Category: Ob fold]] | |||