Rhomboid protease

<StructureSection load='4h1d' size='350' side='right' caption='Structure of rhomboid protease complex with inhibitor DFP (PDB entry 4h1d)' scene=>

Rhomboid protease is a transmembranal serine protease. The active site is buried in the lipid bilayer of cell membrane. It cleaves proteins within their transmembrane domain. Rhomboids regulate many cellular processes and are involved in many human diseases. The catalytic site of rhomboids contains a hydrophilic pocket protected by from the lipid bilayer. Rhomboids are specific for a single transmembranal helix proteins.

3D Structures of rhomboid protease

Updated on 11-July-2013

GlpG

2ic8, 2irv, 2nrf, 2o7l, 3b45, 2xov – EcGlpG core region – Escherichia coli
2xtu, 3b44, 2xtv – EcGlpG core region (mutant)
4hdd – EcGlpG N terminal
2lep – EcGlpG N terminal - NMR
2nr9 – HiGlpG - Haemophilus influenzae
2nr9 – HiGlpG (mutant) + detergent

GlgG complex with inhibitor

2xov, 3zeb – EcGlpG core region + isocoumarin inhibitor
3txt, 4h1d – EcGlpG core region + DFP inhibitor
3ubb – EcGlpG core region + phosphonofluoridate inhibitor
3zmh, 3zmi, [[3zmhj], 3zot – EcGlpG core region + β-lactam inhibitor

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman