CD8: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='3b9k' size='350' side='right' caption='Structure of CD8α and CD8β complex with antibody (PDB entry 3b9k)' scene=''> '''CD8''' (or '''Cluster of Differenti... |
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<StructureSection load='3b9k' size='350' side='right' caption='Structure of CD8α (grey and magenta) and CD8β (green and cyan) complex with antibody heavy chain ( aqua and pink) and light chain (gold and yellow) (PDB entry [[3b9k]])' scene=''> | |||
<StructureSection load='3b9k' size='350' side='right' caption='Structure of CD8α and CD8β complex with antibody (PDB entry [[3b9k]])' scene=''> | |||
'''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell. | '''CD8''' (or '''Cluster of Differentiation 8''') is a T-cell co-receptor. CD8 binds to class I MHC protein. CD8 exists as 2 isoforms: α and β. CD8 forms a dimer of CD8α and CD8β. The extracellular domain of CD8 has immunoglobulin variable-like conformation. This domain of CD8α interacts with α3 domain of class I MHC enhancing the binding of the T-cell receptor and the target cell. | ||
