4ldr: Difference between revisions
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{{STRUCTURE_4ldr| PDB=4ldr | SCENE= }} | |||
===Structure of the S283Y mutant of MRDI=== | |||
{{ABSTRACT_PUBMED_23859498}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MTNA_HUMAN MTNA_HUMAN]] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.<ref>PMID:19620624</ref> | |||
==About this Structure== | |||
[[4ldr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDR OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023859498</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: S-methyl-5-thioribose-1-phosphate isomerase]] | |||
[[Category: Metzner, S I.]] | |||
[[Category: Sousa, M C.]] | |||
[[Category: Templeton, P D.]] | |||
[[Category: Cell invasion]] | |||
[[Category: Helix bundle]] | |||
[[Category: Isomerase]] | |||
[[Category: Rossmann-like fold]] | |||
Revision as of 05:26, 1 August 2013
Structure of the S283Y mutant of MRDI
Template:ABSTRACT PUBMED 23859498
Function
[MTNA_HUMAN] Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.[1]
About this Structure
4ldr is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Templeton PD, Litman ES, Metzner SI, Ahn NG, Sousa MC. Structure of MRDI Explains its Dual Function as a Metabolic Enzyme and a Mediator of Cell Invasion. Biochemistry. 2013 Jul 16. PMID:23859498 doi:10.1021/bi400556e
- ↑ Kabuyama Y, Litman ES, Templeton PD, Metzner SI, Witze ES, Argast GM, Langer SJ, Polvinen K, Shellman Y, Chan D, Shabb JB, Fitzpatrick JE, Resing KA, Sousa MC, Ahn NG. A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme. Mol Cell Proteomics. 2009 Oct;8(10):2308-20. doi: 10.1074/mcp.M900178-MCP200., Epub 2009 Jul 20. PMID:19620624 doi:10.1074/mcp.M900178-MCP200
