4m6w: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4m6w| PDB=4m6w | SCENE= }} | |||
===Crystal structure of the C-terminal segment of FANCM in complex with FAAP24=== | |||
{{ABSTRACT_PUBMED_24003026}} | |||
The entry | ==Disease== | ||
[[http://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN]] ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.<ref>PMID:16116422</ref> <ref>PMID:16116434</ref> [REFERENCE:7][REFERENCE:8] [[http://www.uniprot.org/uniprot/FAP24_HUMAN FAP24_HUMAN]] Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA. | |||
==About this Structure== | |||
[[4m6w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6W OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024003026</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: RNA helicase]] | |||
[[Category: Ding, J.]] | |||
[[Category: Tong, L.]] | |||
[[Category: Yang, H.]] | |||
[[Category: Zhang, T.]] | |||
[[Category: Dna binding protein]] | |||
[[Category: Dna repair]] | |||
[[Category: Faap24]] | |||
[[Category: Fancm]] | |||
[[Category: Fanconi anemia]] | |||
[[Category: Xpf/mus81]] | |||
Revision as of 07:28, 2 October 2013
Crystal structure of the C-terminal segment of FANCM in complex with FAAP24
Template:ABSTRACT PUBMED 24003026
Disease
[FANCM_HUMAN] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.
Function
[FANCM_HUMAN] ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.[1] [2] [REFERENCE:7][REFERENCE:8] [FAP24_HUMAN] Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.
About this Structure
4m6w is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Yang H, Zhang T, Tao Y, Wang F, Tong L, Ding J. Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair. Nucleic Acids Res. 2013 Sep 3. PMID:24003026 doi:10.1093/nar/gkt788
- ↑ Meetei AR, Medhurst AL, Ling C, Xue Y, Singh TR, Bier P, Steltenpool J, Stone S, Dokal I, Mathew CG, Hoatlin M, Joenje H, de Winter JP, Wang W. A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Nat Genet. 2005 Sep;37(9):958-63. Epub 2005 Aug 21. PMID:16116422 doi:ng1626
- ↑ Mosedale G, Niedzwiedz W, Alpi A, Perrina F, Pereira-Leal JB, Johnson M, Langevin F, Pace P, Patel KJ. The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway. Nat Struct Mol Biol. 2005 Sep;12(9):763-71. Epub 2005 Aug 21. PMID:16116434 doi:10.1038/nsmb981
