4m3l: Difference between revisions
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{{STRUCTURE_4m3l| PDB=4m3l | SCENE= }} | |||
===Crystal Structure of the coiled coil domain of MuRF1=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TRI63_HUMAN TRI63_HUMAN]] E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.<ref>PMID:11927605</ref> | |||
==About this Structure== | |||
[[4m3l]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M3L OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Franke, B.]] | |||
[[Category: Mayans, O.]] | |||
[[Category: E3 ubiquitin ligase]] | |||
[[Category: Ligase]] | |||
[[Category: Sarcoskeleton]] | |||
[[Category: Titin]] | |||
Revision as of 09:34, 26 March 2014
Crystal Structure of the coiled coil domain of MuRF1
Function
[TRI63_HUMAN] E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.[1]
About this Structure
4m3l is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ McElhinny AS, Kakinuma K, Sorimachi H, Labeit S, Gregorio CC. Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1. J Cell Biol. 2002 Apr 1;157(1):125-36. Epub 2002 Apr 1. PMID:11927605 doi:https://dx.doi.org/10.1083/jcb.200108089
