4bkk: Difference between revisions
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==The Respiratory Syncytial Virus nucleoprotein-RNA complex forms a left-handed helical nucleocapsid.== | |||
<StructureSection load='4bkk' size='340' side='right' caption='[[4bkk]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4bkk]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_respiratory_syncytial_virus_a_strain_long Human respiratory syncytial virus a strain long]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BKK FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bkk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bkk RCSB], [http://www.ebi.ac.uk/pdbsum/4bkk PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/NCAP_HRSVA NCAP_HRSVA]] Encapsidates the genome, protecting it from nucleases. The nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases.<ref>PMID:9299631</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Respiratory syncytial virus (RSV) is an important human pathogen. Its nucleocapsid (NC), which comprises the negative sense RNA viral genome coated by the viral nucleoprotein N, is a critical assembly that serves as template for both mRNA synthesis and genome replication. We have previously described the X-ray structure of an NC-like structure: a decameric ring formed of N-RNA that mimics one turn of the helical NC. In the absence of experimental data we had hypothesized that the NC helix would be right-handed, as the N-N contacts in the ring appeared to more easily adapt to that conformation. We now unambiguously show that the RSV NC is a left-handed helix. We further show that the contacts in the ring can be distorted to maintain key N-N-protein interactions in a left-handed helix, and discuss the implications of the resulting atomic model of the helical NC for viral replication and transcription. | |||
The respiratory syncytial virus nucleoprotein-RNA complex forms a left-handed helical nucleocapsid.,Bakker SE, Duquerroy S, Galloux M, Loney C, Conner E, Eleouet JF, Rey FA, Bhella D J Gen Virol. 2013 Aug;94(Pt 8):1734-8. doi: 10.1099/vir.0.053025-0. Epub 2013 May, 15. PMID:23677789<ref>PMID:23677789</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== | ==See Also== | ||
*[[Nucleoprotein|Nucleoprotein]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human respiratory syncytial virus a strain long]] | [[Category: Human respiratory syncytial virus a strain long]] | ||
[[Category: Bakker, S E | [[Category: Bakker, S E]] | ||
[[Category: Bhella, D | [[Category: Bhella, D]] | ||
[[Category: Conner, E | [[Category: Conner, E]] | ||
[[Category: Duquerroy, S | [[Category: Duquerroy, S]] | ||
[[Category: Eleouet, J F | [[Category: Eleouet, J F]] | ||
[[Category: Galloux, M | [[Category: Galloux, M]] | ||
[[Category: Loney, C | [[Category: Loney, C]] | ||
[[Category: Rey, F A | [[Category: Rey, F A]] | ||
[[Category: Viral protein-rna complex]] | [[Category: Viral protein-rna complex]] | ||
Revision as of 04:05, 25 December 2014
The Respiratory Syncytial Virus nucleoprotein-RNA complex forms a left-handed helical nucleocapsid.
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