4nyn: Difference between revisions
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{{STRUCTURE_4nyn| PDB=4nyn | SCENE= }} | |||
===Crystal structure of RNase H1 from halophilic archaeon Halobacterium salinarum NRC-1=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/RNH_HALSA RNH_HALSA]] Nuclease that specifically degrades the RNA of RNA-DNA hybrids; seems to act exonucleolytically on RNA/DNA hybrids. Endonucleolytically removes RNA primers from the Okazaki fragments of lagging strand synthesis on its own. Complements the temperature-sensitive phenotype of an E.coli double rnhA/rnhB (RNase H) disruption mutant.<ref>PMID:15115438</ref> | |||
==About this Structure== | |||
[[4nyn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NYN OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Ribonuclease H]] | |||
[[Category: Angkawidjaja, C.]] | |||
[[Category: Kanaya, S.]] | |||
[[Category: Koga, Y.]] | |||
[[Category: You, D J.]] | |||
[[Category: Hydrolase]] | |||
[[Category: Rnase h1]] | |||
Revision as of 05:24, 13 February 2014
Crystal structure of RNase H1 from halophilic archaeon Halobacterium salinarum NRC-1
Function
[RNH_HALSA] Nuclease that specifically degrades the RNA of RNA-DNA hybrids; seems to act exonucleolytically on RNA/DNA hybrids. Endonucleolytically removes RNA primers from the Okazaki fragments of lagging strand synthesis on its own. Complements the temperature-sensitive phenotype of an E.coli double rnhA/rnhB (RNase H) disruption mutant.[1]
About this Structure
4nyn is a 2 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ Ohtani N, Yanagawa H, Tomita M, Itaya M. Identification of the first archaeal Type 1 RNase H gene from Halobacterium sp. NRC-1: archaeal RNase HI can cleave an RNA-DNA junction. Biochem J. 2004 Aug 1;381(Pt 3):795-802. PMID:15115438 doi:https://dx.doi.org/10.1042/BJ20040153
