2mgn: Difference between revisions

Line 1:

~~{{STRUCTURE_2mgn| PDB=2mgn | SCENE= }}~~

==Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3==

===Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3===

~~{{ABSTRACT_PUBMED_24356977}}~~

== Structural highlights ==

<table><tr><td colspan='2'>[[2mgn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MGN FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PQ3:N2,N9-BIS(1-METHYLQUINOLIN-3-YL)-1,10-PHENANTHROLINE-2,9-DICARBOXAMIDE'>PQ3</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mgn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mgn RCSB], [http://www.ebi.ac.uk/pdbsum/2mgn PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Phen-DC3 is a highly promising compound that specifically targets G-quadruplexes, with potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure of the complex formed between Phen-DC3 and an intramolecular G-quadruplex derived from the c-myc promoter. Structural information revealed that Phen-DC3 interacts with the quadruplex through extensive pi-stacking with guanine bases of the top G-tetrad. On the basis of our structure, modifications are proposed for the development of this compound for selective targeting of a specific G-quadruplex conformation.

~~==About this~~ Structure==

Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3.,Chung WJ, Heddi B, Hamon F, Teulade-Fichou MP, Phan AT Angew Chem Int Ed Engl. 2014 Jan 20;53(4):999-1002. doi: 10.1002/anie.201308063. , Epub 2013 Dec 16. PMID:24356977<ref>PMID:24356977</ref>

~~[[2mgn]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2MGN OCA].~~

==~~Reference~~==

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

~~<ref group="xtra">PMID:024356977</ref>~~<references ~~group="xtra"~~/><~~references~~/>

</div>

[[Category: Chung, W J.]]

== References ==

[[Category: Hamon, F.]]

[[Category: Heddi, B.]]

__TOC__

[[Category: Phan, A T.]]

</StructureSection>

[[Category: Teulade-Fichou, M P.]]

[[Category: Chung, W J]]

[[Category: Hamon, F]]

[[Category: Heddi, B]]

[[Category: Phan, A T]]

[[Category: Teulade-Fichou, M P]]

[[Category: C-myc promoter]]

[[Category: Dna]]

[[Category: Ligand]]

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_2mgn|  PDB=2mgn  |  SCENE=  }}
+==Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3==
-===Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3===
+<StructureSection load='2mgn' size='340' side='right' caption='[[2mgn]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
-{{ABSTRACT_PUBMED_24356977}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2mgn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MGN FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PQ3:N2,N9-BIS(1-METHYLQUINOLIN-3-YL)-1,10-PHENANTHROLINE-2,9-DICARBOXAMIDE'>PQ3</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mgn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mgn RCSB], [http://www.ebi.ac.uk/pdbsum/2mgn PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Phen-DC3 is a highly promising compound that specifically targets G-quadruplexes, with potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure of the complex formed between Phen-DC3 and an intramolecular G-quadruplex derived from the c-myc promoter. Structural information revealed that Phen-DC3 interacts with the quadruplex through extensive pi-stacking with guanine bases of the top G-tetrad. On the basis of our structure, modifications are proposed for the development of this compound for selective targeting of a specific G-quadruplex conformation.
-==About this Structure==
+Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3.,Chung WJ, Heddi B, Hamon F, Teulade-Fichou MP, Phan AT Angew Chem Int Ed Engl. 2014 Jan 20;53(4):999-1002. doi: 10.1002/anie.201308063. , Epub 2013 Dec 16. PMID:24356977<ref>PMID:24356977</ref>
-[[2mgn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MGN OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<ref group="xtra">PMID:024356977</ref><references group="xtra"/><references/>
+</div>
-[[Category: Chung, W J.]]
+== References ==
-[[Category: Hamon, F.]]
+<references/>
-[[Category: Heddi, B.]]
+__TOC__
-[[Category: Phan, A T.]]
+</StructureSection>
-[[Category: Teulade-Fichou, M P.]]
+[[Category: Chung, W J]]
+[[Category: Hamon, F]]
+[[Category: Heddi, B]]
+[[Category: Phan, A T]]
+[[Category: Teulade-Fichou, M P]]
 [[Category: C-myc promoter]]
 [[Category: Dna]]
 [[Category: Ligand]]