Dehalogenase: Difference between revisions
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*Haloalkane dehalogenase (HDH) | |||
[[2had]], [[1ede]], [[2pky]], [[2yxp]] – XaHDH – ''Xanthobacter autotrophicus''<br /> | **[[2had]], [[1ede]], [[2pky]], [[2yxp]] – XaHDH – ''Xanthobacter autotrophicus''<br /> | ||
[[1hde]], [[1be0]], [[1bee]], [[1bez]] – XaHDH (mutant)<br /> | **[[1hde]], [[1be0]], [[1bee]], [[1bez]] – XaHDH (mutant)<br /> | ||
[[1bn6]], [[1bn7]], [[4kaa]], [[4kac]], [[4kaf]] – RrHDH – ''Rhodococcus rhodochrous'' <br /> | **[[1bn6]], [[1bn7]], [[4kaa]], [[4kac]], [[4kaf]] – RrHDH – ''Rhodococcus rhodochrous'' <br /> | ||
[[2v9z]] – RrHDH (mutant) <br /> | **[[2v9z]] – RrHDH (mutant) <br /> | ||
[[1cv2]] – SpHDH – ''Sphingomonas paucimobilis''<br /> | **[[1cv2]] – SpHDH – ''Sphingomonas paucimobilis''<br /> | ||
[[4h77]] – SphHDH – ''Sphignobium''<br /> | **[[4h77]] – SphHDH – ''Sphignobium''<br /> | ||
[[4h7d]] – SphHDH (mutant)<br /> | **[[4h7d]] – SphHDH (mutant)<br /> | ||
''Haloalkane dehalogenase complex with halide ion'' | *''Haloalkane dehalogenase complex with halide ion'' | ||
[[1edb]], [[1edd]], [[2eda]], [[2edc]], [[2dhe]], [[1b6g]] – XaHDH + halide<br /> | **[[1edb]], [[1edd]], [[2eda]], [[2edc]], [[2dhe]], [[1b6g]] – XaHDH + halide<br /> | ||
[[1cij]] – XaHDH (mutant) + halide<br /> | **[[1cij]] – XaHDH (mutant) + halide<br /> | ||
[[1d07]], [[1iz7]], [[1k5p]], [[1mj5]] – SpHDH + halide <br /> | **[[1d07]], [[1iz7]], [[1k5p]], [[1mj5]] – SpHDH + halide <br /> | ||
[[3fbw]], [[1cqw]], [[4hzg]] – RrHDH + halide <br /> | **[[3fbw]], [[1cqw]], [[4hzg]] – RrHDH + halide <br /> | ||
[[3a2m]], [[3a2n]], [[3afi]] – BjHDH + halide – ''Bradyrhizobium japonicum''<br /> | **[[3a2m]], [[3a2n]], [[3afi]] – BjHDH + halide – ''Bradyrhizobium japonicum''<br /> | ||
[[3a2l]] – BjHDH (mutant) + halide <br /> | **[[3a2l]] – BjHDH (mutant) + halide <br /> | ||
[[4k2a]] – HDH + halide – ''Bradyrhizobium elkanii''<br /> | **[[4k2a]] – HDH + halide – ''Bradyrhizobium elkanii''<br /> | ||
[[3rk4]], [[3sk0]], [[4f5z]], [[4f60]] – RrHDH (mutant) + halide <br /> | **[[3rk4]], [[3sk0]], [[4f5z]], [[4f60]] – RrHDH (mutant) + halide <br /> | ||
[[4h7e]], [[4h7f]], [[4h7h]], [[4h7i]], [[4h7j]] [[4h7k]] – SphHDH (mutant) + halide <br /> | **[[4h7e]], [[4h7f]], [[4h7h]], [[4h7i]], [[4h7j]] [[4h7k]] – SphHDH (mutant) + halide <br /> | ||
[[4brz]] – RhHDH + halide - ''Rhodobacteraceae''<br /> | **[[4brz]] – RhHDH + halide - ''Rhodobacteraceae''<br /> | ||
''Haloalkane dehalogenase other complexes'' | *''Haloalkane dehalogenase other complexes'' | ||
[[2dhc]] – XaHDH + ethylene dichloride<br /> | **[[2dhc]] – XaHDH + ethylene dichloride<br /> | ||
[[2dhd]] – XaHDH + amono-chloroethoxy-oxobutanoic acid + Cl<br /> | **[[2dhd]] – XaHDH + amono-chloroethoxy-oxobutanoic acid + Cl<br /> | ||
[[1g42]] – SpHDH + dichloropropane + Cl<br /> | **[[1g42]] – SpHDH + dichloropropane + Cl<br /> | ||
[[2bfn]] – SpHDH + dichloropropanol + Cl<br /> | **[[2bfn]] – SpHDH + dichloropropanol + Cl<br /> | ||
[[1g4h]] – SpHDH (mutant) + butanol + Cl<br /> | **[[1g4h]] – SpHDH (mutant) + butanol + Cl<br /> | ||
[[1g5f]] – SpHDH + dichloroethane + Cl<br /> | **[[1g5f]] – SpHDH + dichloroethane + Cl<br /> | ||
[[1iz8]] – SpHDH + propanediol + Cl<br /> | **[[1iz8]] – SpHDH + propanediol + Cl<br /> | ||
[[4c6h]] – RhHDH + hexanol + Cl<br /> | **[[4c6h]] – RhHDH + hexanol + Cl<br /> | ||
[[3fwh]], [[3g9x]], [[4e46]] – RrHDH + isopropanol + Cl <br /> | **[[3fwh]], [[3g9x]], [[4e46]] – RrHDH + isopropanol + Cl <br /> | ||
[[1k6e]] – SpHDH + bromopropanol + Cl + Br<br /> | **[[1k6e]] – SpHDH + bromopropanol + Cl + Br<br /> | ||
[[1k63]] – SpHDH + bromopropene-1-ol + Cl + Br<br /> | **[[1k63]] – SpHDH + bromopropene-1-ol + Cl + Br<br /> | ||
[[4fwb]] – SpHDH (mutant) + trichloropropane + Cl<br /> | **[[4fwb]] – SpHDH (mutant) + trichloropropane + Cl<br /> | ||
*Fluoroacetate dehalogenase (FDH) | |||
[[1y37]] – BuFDH – ''Burkholderia''<br /> | **[[1y37]] – BuFDH – ''Burkholderia''<br /> | ||
[[3r3u]] – RpFDH – ''Rhodopseudomonas palustris''<br /> | **[[3r3u]] – RpFDH – ''Rhodopseudomonas palustris''<br /> | ||
[[3r40]], [[3r41]] – RpFDH (mutant) <br /> | **[[3r40]], [[3r41]] – RpFDH (mutant) <br /> | ||
''Fluoroacetate dehalogenase complexes'' | *''Fluoroacetate dehalogenase complexes'' | ||
[[3r3v]], [[3r3y]] – RpFDH (mutant) + fluoroacetate<br /> | **[[3r3v]], [[3r3y]] – RpFDH (mutant) + fluoroacetate<br /> | ||
[[3r3w]] – RpFDH (mutant) + chloroacetate<br /> | **[[3r3w]] – RpFDH (mutant) + chloroacetate<br /> | ||
[[3r3x]] – RpFDH (mutant) + bromoacetate<br /> | **[[3r3x]] – RpFDH (mutant) + bromoacetate<br /> | ||
[[3r3z]] – RpFDH + glycolate<br /> | **[[3r3z]] – RpFDH + glycolate<br /> | ||
[[3b12]] – BuFDH (mutant) + fluoroacetate<br /> | **[[3b12]] – BuFDH (mutant) + fluoroacetate<br /> | ||
*Halohydrin dehalogenase (HHDH) | |||
[[1zmo]] – HHDH – ''Anthrobacter''<br /> | **[[1zmo]] – HHDH – ''Anthrobacter''<br /> | ||
[[3zn2]] – AtHHDH – ''Agrobacterium tumefaciens''<br /> | **[[3zn2]] – AtHHDH – ''Agrobacterium tumefaciens''<br /> | ||
''Halohydrin dehalogenase complexes'' | *''Halohydrin dehalogenase complexes'' | ||
[[1pwx]] – AtHHDH + Br <br /> | **[[1pwx]] – AtHHDH + Br <br /> | ||
[[1px0]] – AtHHDH + haloalcohol mimic<br /> | **[[1px0]] – AtHHDH + haloalcohol mimic<br /> | ||
[[1zo8]] – AtHHDH + p-nitrostyrene oxide<br /> | **[[1zo8]] – AtHHDH + p-nitrostyrene oxide<br /> | ||
[[4ixt]] – AtHHDH (mutant) + ethyl cyano-hydroxybutyrate<br /> | **[[4ixt]] – AtHHDH (mutant) + ethyl cyano-hydroxybutyrate<br /> | ||
[[4ixw]] – RrHHDH (mutant) + ethyl oxiranyl acetate – ''Rhizobium radiobacter''<br /> | **[[4ixw]] – RrHHDH (mutant) + ethyl oxiranyl acetate – ''Rhizobium radiobacter''<br /> | ||
[[4iy1]] – RrHHDH + Cl<br /> | **[[4iy1]] – RrHHDH + Cl<br /> | ||
*L-2-haloacid dehalogenase (LHDH) | |||
[[1jud]] – PsLHDH – ''Pseudomonas''<br /> | **[[1jud]] – PsLHDH – ''Pseudomonas''<br /> | ||
[[2w43]] – StLHDH – ''Sulfolobus tokodaii''<br /> | **[[2w43]] – StLHDH – ''Sulfolobus tokodaii''<br /> | ||
''L-2-haloacid dehalogenase complexes'' | *''L-2-haloacid dehalogenase complexes'' | ||
[[1aq6]], [[1qq5]] – XaLHDH + formic acid<br /> | **[[1aq6]], [[1qq5]] – XaLHDH + formic acid<br /> | ||
[[1zrm]] – PsLHDH (mutant) + butanoic acid<br /> | **[[1zrm]] – PsLHDH (mutant) + butanoic acid<br /> | ||
[[1zrn]] – PsLHDH (mutant) + acetic acid<br /> | **[[1zrn]] – PsLHDH (mutant) + acetic acid<br /> | ||
[[1qh9]] – PsLHDH + lactic acid<br /> | **[[1qh9]] – PsLHDH + lactic acid<br /> | ||
[[2w11]] – StLHDH + lactic acid <br /> | **[[2w11]] – StLHDH + lactic acid <br /> | ||
[[1qq6]], [[1qq7]] – XaLHDH + aspartate carboxymethyl ester + Cl<br /> | **[[1qq6]], [[1qq7]] – XaLHDH + aspartate carboxymethyl ester + Cl<br /> | ||
*DL-2-haloacid dehalogenase (DLHDH) | |||
[[4n2x]] – MeDLHDH – ''Methylobacterium''<br /> | **[[4n2x]] – MeDLHDH – ''Methylobacterium''<br /> | ||
[[3wj8]] – MeDLHDH + bromo-methylpropionate <br /> | **[[3wj8]] – MeDLHDH + bromo-methylpropionate <br /> | ||
*Iodotyrosine dehalogenase (ITDH) | |||
[[3gb5]] – mITDH – mouse<br /> | **[[3gb5]] – mITDH – mouse<br /> | ||
[[3to0]] – mITDH (mutant) <br /> | **[[3to0]] – mITDH (mutant) <br /> | ||
[[3gfd]] – mITDH + iodotyrosine<br /> | **[[3gfd]] – mITDH + iodotyrosine<br /> | ||
[[3tnz]] – mITDH (mutant) + iodotyrosine<br /> | **[[3tnz]] – mITDH (mutant) + iodotyrosine<br /> | ||
[[3gh8]] – mITDH + diiodotyrosine<br /> | **[[3gh8]] – mITDH + diiodotyrosine<br /> | ||
*cis-3-chloroacrylic acid dehalogenase (CaaD) | |||
[[2flz]], [[3mf8]] – CbCaaD – ''Coryneform bacterium''<br /> | **[[2flz]], [[3mf8]] – CbCaaD – ''Coryneform bacterium''<br /> | ||
[[3mf7]] – CbCaaD + oxirane-carboxylate <br /> | **[[3mf7]] – CbCaaD + oxirane-carboxylate <br /> | ||
[[2flt]] – CbCaaD + lactic acid<br /> | **[[2flt]] – CbCaaD + lactic acid<br /> | ||
*trans-3-chloroacrylic acid dehalogenase (TaaD) | |||
[[3ej3]] – PpTaaD α+β subunits – ''Pseudomonas pavonacea''<br /> | **[[3ej3]] – PpTaaD α+β subunits – ''Pseudomonas pavonacea''<br /> | ||
[[3ej7]], [[3ej9]] – PpTaaD α (mutant) +β subunits <br /> | **[[3ej7]], [[3ej9]] – PpTaaD α (mutant) +β subunits <br /> | ||
[[1s0y]] – PpTaaD α+β subunits + malonic acid <br /> | **[[1s0y]] – PpTaaD α+β subunits + malonic acid <br /> | ||
*5-chloromuconolactone dehalogenase (ClcF) | |||
[[3znu]], [[3znj]], [[4fpi]] – RoClcF – ''Rhodococcus opacus'' <br /> | **[[3znu]], [[3znj]], [[4fpi]] – RoClcF – ''Rhodococcus opacus'' <br /> | ||
[[3zo7]] – RoClcF + 5-chloromuconolactone <br /> | **[[3zo7]] – RoClcF + 5-chloromuconolactone <br /> | ||
*4-chlorobenzoyl CoA dehalogenase (CBCD) | |||
**[[1nzy]] – PsCBCD <br /> | |||
**[[1jxz]] – PsCBCD + hydroxybenzoyl CoA <br /> | |||
}} | |||
Revision as of 11:09, 23 November 2014
<StructureSection load='2edc' size='340' side='right' caption='Structure of haloalkane dehalogenase complex with I- ion (purple) (PDB code 2edc).' scene=>
Function
Dehalogenases catalyze the removal of halogen atom from substrates.
• Haloalkane dehalogenase converts haloalkanes to alcohol
• Halohydrin dehalogenase converts halohydrins to epoxide
• L-2 haloacid dehalogenase converts haloacids to hydroxyacid
• 4-chlorobenzoyl CoA dehalogenase converts 4-chlorobenzoyl CoA to 4-hydroxybenzoyl CoA
• Fluoroacetate dehalogenase converts fluoroacetate to glycolate
• Iodotyrosine dehalogenase converts iodotyrosine to tyrosine
• cis- and trans-3-chloroacrylic acid dehalogenase converts 3-chloroacrylate to malonate semialdehyde
• 5-chloromuconolactone dehalogenase converts 5-chloromuconolactone to E-dienelactone.
Disease
Relevance
Structural highlights
3D structures of dehalogenase
Updated on 23-November-2014
