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<StructureSection load='3cbq' size='450' side='right' scene='' caption='[[2cbq]] '>
[[Image:2nzj.png|left|200px|thumb|Crystal Structure of GTP-binding protein Rem1 tetramer complex with nucleotide [[2nzj]]]]
[[Image:2nzj.png|left|200px|thumb|Crystal Structure of GTP-binding protein Rem1 tetramer complex with nucleotide [[2nzj]]]]
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Revision as of 16:31, 1 December 2014
File:2nzj.png Crystal Structure of GTP-binding protein Rem1 tetramer complex with nucleotide 2nzj
GTP-binding proteins or G proteins are transmitting signals outside the cell which cause changes within the cell. They act as molecular switches which are on when binding GTP and off when binding GDP. GTP-binding proteins belong to two families: heterotrimeric G proteins and small GTPases. See details on GTP-binding protein LpeD in LepA .
An activated G protein-coupled receptor (human β-2 adrenergic receptor in blue ) in a complex with a heterotrimeric G protein (3 subunits:reddish to orange-brown) and hormone (gold) (3sn6 ), resolution 3.2Å. The boundaries of the membrane in which the GPCR sits are represented in light green.
3D Structures of GTP-binding protein Updated on 01-December-2014
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GTP-binding protein 2nzj , LepA – yGtr1 + Gtr2 – yeast3sn6 – hGBP TGS domain – NMR - human3kxk , 3kxl – SsHflx (mutant) - Sulfolobus solfataricus 2qtf – SsHflx1ega – EcERA – Escherichia coli 2dyk – TtEngA N terminal – Thermus thermophilus - Cryo EM3cb4 - EcLepA2ywe – AaLepA1sul – BsYsxC - Bacillus subtilis 2dwq – TtYchF1udx – TtObg1wxq – GBP – Pyrococcus horikoshii 1yr6 - PaGBP – Pyrococcus abyssi 1ni3 – YchF – Schizosaccharomyces pombe GTP-binding protein complex with nucleotide
2nzj – hRem1 + GDP3cbq – hRem2 + GDP3q85 – hRem2 G domain + GTP analog2cjw , 2ht6 , 2g3y – hGem G domain + GDP4aii - rRem2 G domain + GDP - rat2ohf – hOla1 + AMP-PCP1xtq – hRheB + GDP1xts - hRheB + GTP1xtr - hRheB + GPPNHP3sea - hRheB + GDP + GNP1e0a – hGBP (mutant) + GIP2b8w , 2d4h – hGBP N terminal + GMP2b92 - hGBP N terminal + GDP2bc9 - hGBP N terminal + GPPNHP1yr7 , 1yr8 – PaGBP + GTP1yr9 , 1yra , 1yrb , 2oxr – PaGBP + GDP3kxi , 2qth – SsHflx + GDP3ieu – EcERA + GDP 3iev – AaERA + RNA + Mg-GNP – Aquifex aeolicus 1x1l – TtERA + RNA – Cryo EM2ywf – AaLepA + GMP-PNP2ywg - AaLepA + GTP2ywh - AaLepA + GDP1yzn – yPt1 + GPPNHP1ky2 – yPt7 + GPPNHP1ky3 – yPt7 + GDP3rwm , 3rwo – yPt32 + GPPNHP1ek0 – yPt51 + GPPNHP2hjg , 4dcs , 4dct , 4dcu , 4dcv – BsEngA + GDP1svi – BsYsxC + GDP1svw – BsYsxC + GMPPNP1lnz – BsObg + GTP2dby – TtYchF + GDP1wf3 – Tt1341 + GNP2gao - hSar1A + GDP2fa9 – ChSar1B (mutant) + GDP – Chinese hamster2fmx - ChSar1B + GDPGTP-binding protein complex with protein
1x18 – TtERA + RNA + RPS2 + RPS7 + RPS11 + RPS18 – Cryo EM3deg – EcLepA + A-tRNA + P-tRNA + RPS12 + RPL11 – Cryo EM3cue – yPt1 + transport protein subunits2bcg , 1ukv - yPt1 + secretory pathway GDP-dissociation inhibitor3cpj – yPt31 + Rab GDP-dissociation inhibitor1m2o – ySar1 + protein transport protein sec233syn – BsFlhf + ATP-binding proteinG protein bound to a G protein-coupled receptor
3sn6 - human β-2 adrenergic receptor + cameloid antibody fragment bound by guanine nucleotide-binding protein G. This is the first structure of an activated G protein-coupled receptor in a complex with its G protein. Ras-related GTP-binding protein 3llu – hC nucleotide-binding domainRas-related GTP-binding protein complex with nucleotide
2l0x – rRheb + GDP 2gjs – hRad1 + GDP3q72 , 3q7p , 3q7q – hRad G-domain + GTP analog2dpx – hRad GTPase domain2gf0 – hDiRas1 + GDP2erx – hDiRas2 + Pi + GDP1x3s – hRab-18 + GPPNHP1yu9 - hRab-4A + GPPNHP2atx – hTc10 + GPPNHP1g16 – ySec4 + GDP1g17 - ySec4 + GIPRas-related GTP-binding protein complex with protein
3kuc – hRap-1A + proto oncogene Ser/Thr protein kinase3cf6 - hRap-1A + Rap guanine nucleotide exchange factor 43brw - hRap-1B + Rap GTPase-activating protein1z0k – hRab-4 + rabenosyn-53tw8 – hRab-1C + DENNDInterferon-induced GTP-binding protein 3ljb – hMx1 stalk region3szr – hMx1 residues 33-6623zys – hMx1 + dynamin-1Rho-related GTP-binding protein Rho-related GTP-binding protein complex with nucleotide
2cls – hRho6 + GTP2fv8 - hRhoB + GDP2gcn – hRhoC + GDP2gco – hRhoC + GPPNHP1z2c - hRhoC (mutant) + GMPPNP2gcp – hRhoC + GSP1m7b - hRhoE + GTP1gwn - RhoE + GTP - mouse1a4r - hCdc42 (mutant) + GDP1an0 - hCdc42 + GDP2qrz - hCdc42 + GCPRho-related GTP-binding protein complex with protein
2v55 – hRhoE + Rho-associated protein kinase3q3j – hRho6 + plexin-A2 nucleotide-binding domain2rex – hRho6 + plexin-B11cc0 – hRhoA + GDP-dissociation inhibitor + GDP3a58 – yRho1 (mutant) + exocyst complex component Sec31gzs – Cdc42 + guanine nucleotide exchange factor – Salmonella typhimurium 2kb0 - hCdc42 (mutant)1kz7 - hCdc42 + guanine nucleotide exchange factor1kzg - hCdc42 (mutant) + guanine nucleotide exchange factor (mutant)2dfk – hCdc42 + collybistin II2wm9 , 2wmn , 2wmo - hCdc42 + DOCK93eg5 - hCdc42 + protein diaphanous homolog 1 + GMPPNP3gcg - hCdc42 + MAP3n3v - hCdc42 + AMP-protein transferase1nf3 - hCdc42 + Par62ase - hCdc42 (mutant) - NMR1ki1 – hCdc42 + intersectin long form1ees – hCdc42 + MapK3 peptide - NMR1doa - hCdc42 + GDP-dissociation inhibitor2ngr – hCdc42 + GTPase-activating protein C terminal + GDP1am4 – hCdc42 + GTPase-activating protein rhoGAP + GNP1grn – hCdc42 + GTPase-activating protein rhoGAP + GDP1cf4 – hCdc42 (mutant) + ACK GTPase-binding domain + GNP - NMR1cee – hCdc42 + WASP GTPase-binding domain + GCP - NMR2odb – hCdc42 + PAK6 CRIB domain + GCP 3qbv – hCdc42 (mutant) + intersectin + GDP 4did – hCdc42 + inositol phosphate phosphatase + GDP 1cf4 – hCdc42 (mutant) + dedicator of cytokinesis protein 84itr – hCdc42 + AMP-protein transferase + GDP + AMPRac-like GTP-binding protein 2wbl – AtArac2 + Rho of plant guanine nucleotide exchange factor 8 – Arabidopsis thaliana 3bwd – AtArac62nty – AtArac5 + prone82j0v – AtArac7 (mutant)Rab-related GTP-binding protein 2ys8 – hRabJ DNAJ domain – NMRFlagella-associated GTP-binding protein 2px0 – BsFlhF + GMP-PNP 2px3 – BsFlhF + GTPSmall GTP-binding protein 2rhd – GBP – Cryptosporidium parvum 1yzq - hRab-6 + GNP3qq5 – GBP – Thermotoga neapolitana GTP-binding protein Ran Ran binary complex
3gj0 – hRan + GDP1i2m – hRan + regulator of chromosome condensation 11byu – Ran + GDP - dog1qg2 , 1qg4 , 3ran – dRan (mutant) + GDP2bku – dRan + importinRan ternary complex
1rrp – hRan + Nup358 + GTP analog1qbk – hRan + karyopherin β2 + GTP analog1ibr – hRan + importin β1 subunit + GTP analog3ea5 – hRan (mutant) + importin β1 subunit + GDP 4c0q - hRan (mutant) + importin 12 + GTP 3nc1 – hRan (mutant) + exportin 1 + GTP 3ch5 , 3gj3 , 3gj4 , 3gj5 , 3gj6 , 3gj7 , 3gj8 – hRan + Nup153 + GDP3w3z – dRan + importin β1 subunit + GTP Ran quaternary complex
3gjx – hRan + snurportin 1 + exportin 1 + GTP 3nby , 3nbz , 3nc0 – hRan (mutant) + snurportin 1 + exportin 1 + GTP 1k5d – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GTP analog1k5g – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GDP 4gpt , 4gmx , 4hat , 4hb2 , 4hb3 – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP 4hat , 4hau , 4hav , 4haw , 4hax , 4hay , 4haz , 4hb0 , 4hb4 – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP + antibiotic3zjy – hRan (mutant) + importin 13 + EIF-1A + GTP 3a6p – dRan + pre-microRNA + exportin 5 + peptide 3icq – yRan + RNA + exportin T 3m1i – yRan + Ran-specific GTPase-activating protein + exportin 1 + GTP See Also proteopedia link
