3qt2

Structure of a cytokine ligand-receptor complex

spinqualitylabelsall models 3qt2, resolution 2.55Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3qt2 is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: BGC, MPD Gene: IL5R, IL5RA (Homo sapiens), IL5 (Homo sapiens) Resources: FirstGlance, OCA, RCSB, PDBsum Function [IL5RA_HUMAN] This is the receptor for interleukin-5. The alpha chain binds to IL5. [IL5_HUMAN] Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells. Publication Abstract from PubMed Interleukin-5 (IL-5) is the key mediator for the function of eosinophil granulocytes, whose deregulation is characteristic of hypereosinophilic diseases and presumably contributes to allergic asthma. IL-5 signaling involves two transmembrane receptors, IL-5Ralpha and the common beta chain, which upon formation of the ternary complex activate the JAK/STAT signaling cascade. To investigate the mechanism underlying ligand-receptor recognition, we determined the structure of IL-5 bound to the extracellular domain of IL-5Ralpha. IL-5 makes contact with all three fibronectin III-like domains of IL-5Ralpha, with the receptor architecture resembling a wrench. Mutagenesis data provide evidence that this wrench-like architecture is likely preformed. The structure demonstrates that for steric reasons, homodimeric IL-5 can bind only one receptor molecule, even though two equivalent receptor-binding sites exist. In regard to strong efforts being made to develop IL-5 antagonists for treating asthma and hypereosinophilic diseases, the advances in molecular understanding provided by this structure are of greatest value. Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Ralpha.,Patino E, Kotzsch A, Saremba S, Nickel J, Schmitz W, Sebald W, Mueller TD Structure. 2011 Dec 7;19(12):1864-75. PMID:22153509 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Interleukin Interleukin receptor

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