3x0e: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of the ectodomain of human CD81 large extracellular loop (hCD81-LEL)==

~~The entry~~ 3x0e is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[3x0e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X0E OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X0E FirstGlance].

~~Authors~~: ~~Zhang~~, M., ~~Cui~~, S.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

~~Description~~: ~~Structure~~ of the ~~ectodomain~~ of a ~~tetraspanin~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x0e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3x0e RCSB], [http://www.ebi.ac.uk/pdbsum/3x0e PDBsum]</td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:[http://omim.org/entry/613496 613496]]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:20237408</ref>

== Function ==

[[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.

== References ==

__TOC__

</StructureSection>

[[Category: Cui, S]]

[[Category: Zhang, M]]

[[Category: ~~Cui, S~~]]

[[Category: Activation]]

[[Category: Cell adhesion]]

[[Category: Differentiation]]

[[Category: Disulfide bond]]

[[Category: Helical bundle]]

[[Category: Immune cell adhesion]]

[[Category: Morphology]]

[[Category: Proliferation]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of the ectodomain of human CD81 large extracellular loop (hCD81-LEL)==
+<StructureSection load='3x0e' size='340' side='right' caption='[[3x0e]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
-The entry 3x0e is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3x0e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X0E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X0E FirstGlance]. <br>
-Authors: Zhang, M., Cui, S.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g8q|1g8q]], [[1iv5|1iv5]], [[3x0f|3x0f]], [[3x0g|3x0g]]</td></tr>
-Description: Structure of the ectodomain of a tetraspanin
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x0e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3x0e RCSB], [http://www.ebi.ac.uk/pdbsum/3x0e PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:[http://omim.org/entry/613496 613496]]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:20237408</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN]] May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Cui, S]]
 [[Category: Zhang, M]]
-[[Category: Cui, S]]
+[[Category: Activation]]
+[[Category: Cell adhesion]]
+[[Category: Differentiation]]
+[[Category: Disulfide bond]]
+[[Category: Helical bundle]]
+[[Category: Immune cell adhesion]]
+[[Category: Morphology]]
+[[Category: Proliferation]]