Factor VIII: Difference between revisions
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[[Factor VIII]] (FVIII) is a blood clotting factor | <StructureSection load='2r7e' size='350' side='right' scene='' caption='Glycosylated human Factor VIII. Residues 19-760 (grey) 1582-2351 (green) complex with Ca+2 (green) and Cu+2 (orange) ions (PDB code [[2r7e]]) '> | ||
== Function == | |||
[[Factor VIII]] (FVIII) is a blood clotting factor. FVIII is a cofactor for [[Factor IX|factor IXa]]<ref>PMID:2491949</ref> . See also [[Factor VIII (Hebrew)]]. | |||
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The A subunit is composed of an activation peptide and 4 domains: the β-sandwich <scene name='1f13/Chaina_domain1/1'>domain</scene>, the central core domain, the barrel 1 domain, and the | The A subunit is composed of an activation peptide and 4 domains: the β-sandwich <scene name='1f13/Chaina_domain1/1'>domain</scene>, the central core domain, the barrel 1 domain, and the | ||
<scene name='1f13/Fxiii_4domains_colored/1'>barrel 2 domain</scene>.--> | <scene name='1f13/Fxiii_4domains_colored/1'>barrel 2 domain</scene>.--> | ||
== Disease == | |||
Defects in the protein result in hemophilia A. | |||
== Relevance == | |||
Factor VIII is given to hemophiliacs in order to restore homestasis. | |||
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</StructureSection> | |||
== 3D Structures of Factor VIII == | == 3D Structures of Factor VIII == | ||
