Rhomboid protease

spinqualitylabelsall models Structure of rhomboid protease complex with inhibitor DFP (PDB entry 4h1d) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Rhomboid protease is a transmembranal serine protease. The active site is buried in the lipid bilayer of cell membrane. It cleaves proteins within their transmembrane domain. Rhomboids regulate many cellular processes and are involved in many human diseases. The catalytic site of rhomboids contains a hydrophilic pocket protected by from the lipid bilayer. Rhomboids are specific for a single transmembranal helix proteins.

3D Structures of rhomboid protease

Updated on 10-August-2016

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• Rhomboid protease
  • 2ic8, 2irv, 2nrf, 2o7l, 3b45, 2xov, 4njn, 4njp – EcGlpG core region – Escherichia coli
    
  • 2xtu, 3b44, 2xtv – EcGlpG core region (mutant)
    
  • 4hdd – EcGlpG N terminal
    
  • 2lep, 2mja – EcGlpG N terminal - NMR
    
  • 3odj – HiGlpG - Haemophilus influenzae
    
  • 2nr9 – HiGlpG (mutant) + detergent
    
  • 2gqc – RP N terminal – NMR – Pseudomonas aeruginosa
    
• Rhomboid protease complex with inhibitor
  • 2xow, 3zeb – EcGlpG core region + isocoumarin inhibitor
    
  • 3txt, 4h1d – EcGlpG core region + DFP inhibitor
    
  • 3ubb – EcGlpG core region + phosphonofluoridate inhibitor
    
  • 3zmh, 3zmi, 3zmj, 3zot – EcGlpG core region + β-lactam inhibitor
    
  • 4qnz – EcGlpG core region (mutant) + peptide inhibitor
    
  • 4qo0, 4qo2 – EcGlpG core region + peptide inhibitor
    

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Michal Harel, Alexander Berchansky, Joel L. Sussman