Symplekin: Difference between revisions
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<StructureSection load='3o2s' size='340' side='right' caption='Human symplekin N terminal (grey) complex with RNA polymerase II subunit A C terminal phosphatase (green) and phosphate ion (PDB code [[3o2s]])' scene=''> | <StructureSection load='3o2s' size='340' side='right' caption='Human symplekin N terminal (grey) complex with RNA polymerase II subunit A C terminal phosphatase (green) and phosphate ion (PDB code [[3o2s]])' scene=''> | ||
== Function == | == Function == | ||
'''Symplekin''' (SMPK) is a scaffold protein recruiting regulatory factors to the multimolecular complex involved in histone mRNA 3’-end processing. SMPK is involved in pre-mRNA polyadenylation. It enhances the activity of RNA polymerase II subunit A C terminal phosphatase (Ssu72)<ref>PMID:8769423</ref>. | |||
== Relevance == | == Relevance == | ||
Overexpression of SMPK promotes tumorigenicity in the colon<ref>PMID20133805</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
