BtuB: Difference between revisions
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<StructureSection load='3m8d' size='450' side='right' scene= caption=' | <StructureSection load='3m8d' size='450' side='right' scene= caption='E. coli BtuB complex with cyanocobalmine, lipid, methanesulfonothioate derivative and Ca+2 ions (green) (PDB code [[3m8d]])'> | ||
'''BtuB''' is an outer membrane receptor found in a variety of bacteria, such as ''E. coli''. BtuB transports vitamin B12 across the membrane of gram-negative bacteria. The transport is achieved with high affinity by the collaboration of BtuB and the periplasmic protein TonB. As an essential receptor for the cell that is constitutively expressed, it is an ideal target to be parasitized, a feature exploited by a variety of proteins such as [[Colicin]]s. | '''BtuB''' is an outer membrane receptor found in a variety of bacteria, such as ''E. coli''. BtuB transports vitamin B12 across the membrane of gram-negative bacteria. The transport is achieved with high affinity by the collaboration of BtuB and the periplasmic protein TonB. As an essential receptor for the cell that is constitutively expressed, it is an ideal target to be parasitized, a feature exploited by a variety of proteins such as [[Colicin]]s. | ||
==3D structure of BtuB== | ==3D structure of BtuB== | ||
Revision as of 11:22, 12 November 2015
<StructureSection load='3m8d' size='450' side='right' scene= caption='E. coli BtuB complex with cyanocobalmine, lipid, methanesulfonothioate derivative and Ca+2 ions (green) (PDB code 3m8d)'>
BtuB is an outer membrane receptor found in a variety of bacteria, such as E. coli. BtuB transports vitamin B12 across the membrane of gram-negative bacteria. The transport is achieved with high affinity by the collaboration of BtuB and the periplasmic protein TonB. As an essential receptor for the cell that is constitutively expressed, it is an ideal target to be parasitized, a feature exploited by a variety of proteins such as Colicins.
3D structure of BtuB
Updated on 12-November-2015
2guf, 1nqe, 1nqf – EcBtuB – Escherichia coli
3m8b, 3rgm, 3rgn – EcBtuB (mutant)
3m8d - EcBtuB (mutant) + cyanocobalamin
1nqh - EcBtuB + cyanocobalamin + Ca
2ysu - EcBtuB + Colicin E2 receptor binding domain
1ujw - EcBtuB + Colicin E3 receptor binding domain
2gsk - EcBtuB + TonB C-terminal
1nqg - EcBtuB + Ca
2bto – PdBtuBA + thioredoxin – Prosthecobacter dejongeii
2btq – PdBtuBA + PdBtuBB
