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| '''CD1''' (or '''Cluster of Differentiation 1''') is related to class I MHC molecules. CD1 is expressed on the surface of antigen presenting cells and presents lipid antigens to T cells. There are 3 groups of CD1 differing in their lipid anchoring. Group 1 contains CD1a, CD1b and CD1c. Group 2 contains CD1d. Group 3 contains CD1e. CD1 structure is comprised of a heavy chain with a1, a2 and a3 domains which is non-covalently associated with β-microglobulin. CD1 contains a larger and deeper antigen binding groove than class I MHC molecules.<ref>PMID:17593656</ref> | | '''CD1''' (or '''Cluster of Differentiation 1''') is related to class I MHC molecules. CD1 is expressed on the surface of antigen presenting cells and presents lipid antigens to T cells. There are 3 groups of CD1 differing in their lipid anchoring. Group 1 contains CD1a, CD1b and CD1c. Group 2 contains CD1d. Group 3 contains CD1e. CD1 structure is comprised of a heavy chain with a1, a2 and a3 domains which is non-covalently associated with β-microglobulin. CD1 contains a larger and deeper antigen binding groove than class I MHC molecules.<ref>PMID:17593656</ref> |
| *<scene name='55/551229/Cv/2'>Mouse CD1 extracellular domain with β-microglobulin complex and glycolipid</scene>(PDB entry [[3ilp]]).<ref>PMID:20080535</ref> | | *<scene name='55/551229/Cv/2'>Mouse CD1 extracellular domain with β-microglobulin complex and glycolipid</scene> (PDB entry [[3ilp]]).<ref>PMID:20080535</ref> |
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Revision as of 10:47, 29 November 2015
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CD1 (or Cluster of Differentiation 1) is related to class I MHC molecules. CD1 is expressed on the surface of antigen presenting cells and presents lipid antigens to T cells. There are 3 groups of CD1 differing in their lipid anchoring. Group 1 contains CD1a, CD1b and CD1c. Group 2 contains CD1d. Group 3 contains CD1e. CD1 structure is comprised of a heavy chain with a1, a2 and a3 domains which is non-covalently associated with β-microglobulin. CD1 contains a larger and deeper antigen binding groove than class I MHC molecules.[1]
- ↑ Zajonc DM, Wilson IA. Architecture of CD1 proteins. Curr Top Microbiol Immunol. 2007;314:27-50. PMID:17593656
- ↑ Wang J, Li Y, Kinjo Y, Mac TT, Gibson D, Painter GF, Kronenberg M, Zajonc DM. Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells. Proc Natl Acad Sci U S A. 2009 Dec 30. PMID:20080535
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3D Structures of CD1
Updated on 29-November-2015
{"openlevels":0}
- CD1d
- 3ilp, 1cd1 – mCD1 extracellular domain + β-microglobulin - mouse
- CD1 complex with glycolipid
- 1z5l – mCD1 extracellular domain + β-microglobulin + decahexne + octahexane
- 1zhn – mCD1 extracellular domain + β-microglobulin + phosphatidyl choline
- 2akr – mCD1 extracellular domain + β-microglobulin + sulfatide
- 2fik – mCD1 extracellular domain + β-microglobulin + glycosphingolipid
- 2gaz, 3ilp, 3ilq, 3t1f – mCD1 extracellular domain + β-microglobulin + lipoglycan
- 2q7y – mCD1 extracellular domain + β-microglobulin + IGB3
- 3gml, 3gmm, 3gmn, 3gmo, 3gmp, 3gmr – mCD1 extracellular domain + β-microglobulin + octadecane
- 3g08 – mCD1 extracellular domain + β-microglobulin + ceramide
- 3ma7 – mCD1 extracellular domain + β-microglobulin + cardiolipin
- 1z5l – mCD1 extracellular domain + β-microglobulin + ganglioside
- CD1 complex with glycolipid and T-cell receptor protein
- 3he6, 3he7, 3o8x, 3o9w, 3arb, 3ard, 3are, 3arf, 3arg, 3qux, 3quy, 3quz, 3rug, 3rzc, 3scm, 3sda, 3sdc, 3sdd, 3ta3, 3tn0, 3to4, 3tvm, 3qi9, 3rtq – mCD1 extracellular domain + β-microglobulin + glycolipid + T-cell receptor NKT
- 4ei5, 4elm, 4apq – mCD1 extracellular domain + β-microglobulin + sulfatide + T-cell receptor NKT
- 3ubx – mCD1 extracellular domain + β-microglobulin + glycolipid+ antibody
References
