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| <StructureSection load='3mx0' size='340' side='right' caption='Structure of glycosylated human ephrin-A5 receptor-binding domain (green and yellow) complex with ephrin type A receptor 2 (grey and pink) (PDB code [[3mx0]]).' scene=''> | | <StructureSection load='3mx0' size='340' side='right' caption='Structure of glycosylated human ephrin-A5 receptor-binding domain complex with ephrin type A receptor 2 (PDB code [[3mx0]]).' scene='59/594659/Cv/1'> |
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| == Function == | | == Function == |
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| == Disease == | | == Disease == |
| Eph-A5 is implicated in spinal cord injury. Eph-A1 is implicated in myocardial injury and renal reperfusion injury. | | Eph-A5 is implicated in spinal cord injury. Eph-A1 is implicated in myocardial injury and renal reperfusion injury. |
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| | == Structural highlights == |
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| | <scene name='59/594659/Cv/2'>Ephrin-A5 receptor-binding domain complex with ephrin type A receptor 2</scene> (PDB code [[3mx0]]).<ref>PMID:20505120</ref> |
| </StructureSection> | | </StructureSection> |
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Revision as of 13:26, 9 February 2016
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Function
Ephrins (Eph) are the membrane-bound ligands of ephrin receptors. The binding of Eph and ephrin receptors is achieved via cell-cell interaction. Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation [1].
Disease
Eph-A5 is implicated in spinal cord injury. Eph-A1 is implicated in myocardial injury and renal reperfusion injury.
Structural highlights
Ephrin-A5 receptor-binding domain complex with ephrin type A receptor 2 (PDB code 3mx0).[2]
- ↑ Egea J, Klein R. Bidirectional Eph-ephrin signaling during axon guidance. Trends Cell Biol. 2007 May;17(5):230-8. Epub 2007 Apr 8. PMID:17420126 doi:https://dx.doi.org/10.1016/j.tcb.2007.03.004
- ↑ Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S. Architecture of Eph receptor clusters. Proc Natl Acad Sci U S A. 2010 May 26. PMID:20505120
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3D structures of ephrin
Updated on 09-February-2016
{"openlevels":0}
- Ephrin-A5
- 3mx0 – mEph receptor-binding domain – mouse
- 1shw – mEph residues 88-225 + Eph type B receptor 2
- 2x11, 3mx0 – hEph receptor-binding domain + Eph type A receptor 2 - human
- 4bk5, 4bka, 4m4r – hEph receptor-binding domain + Eph type A receptor 4
- 4l0p – hEph receptor-binding domain + Eph type A receptor 3
- Ephrin-B2
- 2i85 – hEph residues 1-142 – NMR
- 1iko – mEph ectodomain
- 1kgy – mEph receptor-binding domain + Eph type B receptor 2
- 2hle – mEph receptor-binding domain + Eph type B receptor 4
- 2wo2, 3gxu – hEph receptor-binding domain + Eph type A receptor 4
- 2vsk, 2vsm – hEph receptor-binding domain + virus hemagglutinin neuraminidase
- Ephrin-B3
- 3d12 – mEph receptor-binding domain + virus hemagglutinin neuraminidase
- 4bkf – hEph receptor-binding domain + Eph type A receptor 4
- Ephrin-A1
- 3hei, 3mbw, 3czu – hEph receptor-binding domain + Eph type A receptor 2
- 3fl7 – hEph ectodomain
- Ephrin-A2
- 2wo3 – hEph receptor-binding domain + Eph type A receptor 4
- Ephrin-A3
- 3dzq – hEph kinase domain + inhibitor
References
