Fibroblast growth factor: Difference between revisions
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<StructureSection load='2uus' size='350' side='right' scene='' caption='Rat fibroblast growth factor 1 complex with heparan sulfate (PDB code [[2uus]]) '> | <StructureSection load='2uus' size='350' side='right' scene='' caption='Rat fibroblast growth factor 1 complex with heparan sulfate (PDB code [[2uus]]) '> | ||
== Function == | == Function == | ||
'''Fibroblast growth factors''' (FGF) are involved in angiogenesis, wound-healing and embryonic development. FGF is heparin-binding protein. FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR). In vertebrates there are 23 members in the FGF family<ref>PMID: | '''Fibroblast growth factors''' (FGF) are involved in angiogenesis, wound-healing and embryonic development. FGF is heparin-binding protein. FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR). In vertebrates there are 23 members in the FGF family<ref>PMID:11276432</ref>. <br /> | ||
* '''FGF1''' is called acidic FGF.<br /> | * '''FGF1''' is called acidic FGF.<br /> | ||
* '''FGF2''' is called basic FGF.<br /> | * '''FGF2''' is called basic FGF.<br /> | ||
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== Relevance == | == Relevance == | ||
FGF signaling is important in the pathogenesis of a variety of tumor types. | FGF signaling is important in the pathogenesis of a variety of tumor types, angiogenesis and wound healing. | ||
</StructureSection> | </StructureSection> | ||
