5hix: Difference between revisions
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==Cocrystal structure of an anti-parallel DNA G-quadruplex and a tetra-Quinoline Foldamer== | |||
<StructureSection load='5hix' size='340' side='right' caption='[[5hix]], [[Resolution|resolution]] 2.48Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5hix]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HIX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HIX FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=61Q:4-(3-aminopropoxy)-8-({[4-(3-aminopropoxy)-8-({[4-(3-aminopropoxy)-8-({[4-(3-aminopropoxy)-8-nitroquinolin-2-yl]carbonyl}amino)quinolin-2-yl]carbonyl}amino)quinolin-2-yl]carbonyl}amino)quinoline-2-carboxylic+acid'>61Q</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hix OCA], [http://pdbe.org/5hix PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hix RCSB], [http://www.ebi.ac.uk/pdbsum/5hix PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hix ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Quinoline-based oligoamide foldamers have been identified as a potent class of ligands for G-quadruplex DNA. Their helical structure is thought to target G-quadruplex loops or grooves and not G-tetrads. We report a co-crystal structure of the antiparallel hairpin dimeric DNA G-quadruplex (G4 T4 G4 )2 with tetramer 1-a helically folded oligo-quinolinecarboxamide bearing cationic side chains-that is consistent with this hypothesis. Multivalent foldamer-DNA interactions that modify the packing of (G4 T4 G4 )2 in the solid state are observed. | |||
Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State.,Mandal PK, Baptiste B, Langlois d'Estaintot B, Kauffmann B, Huc I Chembiochem. 2016 Oct 17;17(20):1911-1914. doi: 10.1002/cbic.201600281. Epub 2016, Aug 19. PMID:27472456<ref>PMID:27472456</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 5hix" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Baptiste, B]] | [[Category: Baptiste, B]] | ||
[[Category: | [[Category: Estaintot, B Langlois d]] | ||
[[Category: Huc, I]] | |||
[[Category: Kauffmann, B]] | [[Category: Kauffmann, B]] | ||
[[Category: | [[Category: Mandal, P K]] | ||
[[Category: | [[Category: Dna]] | ||
[[Category: Dna g-quadruplex]] | |||
[[Category: Foldamer]] | |||
[[Category: Foldamer-quadruplex]] | |||
[[Category: G-quadruplex ligand]] | |||
Revision as of 18:15, 2 November 2016
Cocrystal structure of an anti-parallel DNA G-quadruplex and a tetra-Quinoline Foldamer
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