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| '''Response regulators''' (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments. | | '''Response regulators''' (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments. |
| Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal shich is the signal receiving domain and C terminal which is the DNA-binding domain. RR CheY is a chemotaxis response regulator in bacteria. RR Spo0 is the sporulation response regulator. For details see:<br /> | | Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal which is the signal receiving domain and C terminal which is the DNA-binding domain. |
| For PleD:<br />
| | |
| *[[PleD activation]]<br />
| | *'''RR CheY''' is a chemotaxis response regulator in bacteria<ref>PMID:14563873</ref>. <br /> |
| *[[PleD allosteric product inhibition]]<br />
| | *'''RR Spo0''' is the sporulation response regulator<ref>PMID:12829280</ref>. <br /> |
| *[[PleD catalysis]]<br />
| | *'''RR PleD''' is required in loss of motility<ref>PMID:7592388</ref>. For details see [[PleD activation]], [[PleD allosteric product inhibition]], [[PleD catalysis]] and [[Response regulator PLED in complex with C-di-GMP]]<br /> |
| *[[Response regulator PLED in complex with C-di-GMP]]<br />
| | *'''RR PhoP''' is important for survival under conditions of macrophage-induced stress<ref>PMID:7592388</ref>. For details see [[PhoP Regulatory Domain]] and [[PhoP-PhoQ]]<br /> |
| For PhoP:<br />
| | |
| *[[PhoP Regulatory Domain]]<br />
| |
| *[[PhoP-PhoQ]]<br />
| |
| For photosynthetic apparatus RR:<br /> | | For photosynthetic apparatus RR:<br /> |
| *[[PrrA in Rhodobacter sphaeroides]] <br /> | | *[[PrrA in Rhodobacter sphaeroides]] <br /> |
Template:STRUCTURE 1kgs
Response regulators (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments.
Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal which is the signal receiving domain and C terminal which is the DNA-binding domain.
For photosynthetic apparatus RR:
For WspR RR:
3D Structures of response regulator
Updated on 07-August-2016
{"openlevels":0}
- Nitrate/nitrite response regulator
- Sporulation response regulator
- 1srr, 2jvi, 2jvj, 2jvk – BsSpo0F (mutant) – Bacillus subtilis
- 1nat - BsSpo0F
- 3q15 - BsSpo0F + RR aspartate phosphatase
- 1ixm - BsSpo0B
- 1fc3 – GsSpo0A trans-activation domain – Geobacillus stearothermophilus
- 1dz3, 1qmp - GsSpo0A reciever domain
- DNA-binding response regulator
- 1kgs – TmDrrD – Thermotoga maritima
- 3nnn – TmDrrD receiver domain + BeF3
- 1p2f – TmDrrB
- 3nns - TmDrrB receiver domain + BeF3
- 1nxo, 1nxp, 1nxs, 1nxt, 1nxv, 1nxw, 1nxx – SpMicArec receiver domain – Streptococcus pneumonia
- 2gwr - MtMtrA – Mycobacterium tuberculosis
- 2hwv – EfVicR C terminal – Enterococcus faecalis
- 2qsj – LuxR – Silicibbacter pomeroyi
- 3cnb, 3eqz – MerR receiver domain – Colwellia psychrerythraea
- 2rnj – SaVraR DNA-binding domain – Staphylococcus aureus – NMR
- 2zxj - SaWalR DNA-binding domain
- 4gvp – SaVraR
- 4if4 – SaVraR + Mg + BeF3
- 3q9s – DrRR receiver domain – Deinococcus radiodurans
- 3q9v - DrRR C terminal
- 3rjp - RR DNA -binding domain – Streptococcus pyogenes
- 2a9r – SpRR N terminal + phosphate + Mg
- Cyanobacterial phytochrome response regulator
- 1i3c – SyRcp1 – Synechocystis
- 1jlk – SyRcp1 + Mn
- 1k66 – ToRcpB – Tolypothrix
- 1k68 – ToRcpB
- Phosphatase synthesis response regulator
- 1mvo – BsPhoP receiver domain
- 2jb9, 2jba – EcPhoB (mutant)
- 2pmu – MtPhoP DNA-binding domain
- Polar differentiation response regulator
- Photosynthetic apparatus response regulator
- 1umq – PrrA DNA-binding domain – Rhodobacter sphaeroides – NMR
- 1ys6 – MtPrrA
- 1ys7 – MtPrrA + Mg
- Redox response regulator
- 1xhe – EcArcA receiver domain
- 1xhf – EcArcA receiver domain + BeF3
- 2y79 – MtDevs GAF domain (mutant)
- 3zxo - MtDevs ATP-binding domain (mutant)
- Social motility response regulator
- 2gkg, 2i6f – MxFrzS receiver domain – Myxococcus xanthus
- 2nt3, 2nt4 - MxFrzS receiver domain (mutant)
- Stalked-cell differentiation response regulator
- Hypoxia response regulator
- 3c3w, 1zlj – MtDosR
- 3c57 – MtDosR C terminal
- 1zlk – MtDosR C terminal + DNA
- 3zxo – MtDost ATP-binding domain
- Transcriptional response regulator
- 2zwm – BsYycF receiver domain
- 3ulq – BsComA DNA-binding domain + RR aspartate phosphatase
- 2pkx – EcPhoP regulatory domain
- 3nhz – MtMtra N terminal
- Stress response regulator
- Chemotaxis response regulator
- 3t8y - EcCheB
- 1mih, 1jbe – EcCheY
- 1p6q – SmCheY2 - Sinorhizobium meliloti
- 1p6u – SmCheY2 + BeF3
- 3hzh – CheY-3 + CheX – Borrelia burgdorferi
- 1u0s – TmCheY + CheA
- 2chy – CheY – Salmonella typhimurium
- CheY-like response regulator
- 3snk – RR – Mesorhizobium loti
- 3cg4, 3crn - RR receiver domain – Methanospirillum hungatei
- 3i42 – RR receiver domain – Methylobacter flagellates
- 3bre – PaRR – Pseudomonas aeruginosa
- Two-component response regulator
- 2lpm – SmRR
- 2m98 – RR – Sinorhizobium meliloti
- 4q7e – RR receiver domain – Leptospira biflexa
- 2qr3 – RR N terminal – Bacteroides fragilis
- 2qzj – RR – Clostridium difficile
- 3cz5 – RR – Aurantimonas
- response regulator receiver domain protein
- 4wsz – EfRR
- 3c3m – RR – Methanoculleus marisnigri
- 3heb - RR – Rhodospirillum rubrum
- 3lte – RR – Bermanella marisrubri
- 3jte, 3lua – RR – Clostridium thermocellum
- 4wt0 – EfRR DNA-binding domain (mutant)
- 4wu4, 4wuh, 4wul – EfRR DNA-binding domain + DNA
- 4xlt – RR – Dyadobacter fermentans
- Unspecified response regulator
- 1yio, 1zn2 – StyR – Pseudomonas fluorescens
- 3a0u, 3a10 – TmTrrA + Mg + BeF3
- 2qvg – RR – Legionella pneumophila
- 3gl9, 2qxy, 4ja2 - TmRR
- 4hye – SpRR
- 2zay – RR – Desulfuromonas acetoxidans
- 2rdm – RR (mutant) – Sinorhizobium medicae
- 3hdv – RR – Pseudomonas putida
- 3i5a – PsWspR – Pseudomonas syringae
- 3ilh – RR – Cytophaga hutchinsonii
- 3i5b – PaWspR GGDEF domain
- 3i5c – PaWspR GGDEF domain/GCN4 leucine zipper
- 3ljx – McMmoQ – Methylococcus capsulatus
- 3p3q – McMmoQ (mutant)
- 3lsg – RR C terminal – Fusobacterium nucleatum
- 3nhm – MxRR
- 3m6m – XcRpfC REC domain + enoyl-CoA hydratase – Xanthomonas campestris
- 3qyy – XcRR GGDEF domain + GMP
- 3p01 – RR residues 134-315 – Nostoc
- 3rqi – RR + phosphate + Ca + citrate – Burkholderia pseudomallei
- 3kto – RR - Pseudoalteromonas atlantica
- 3t0y – CvRR anti-anti-σ domain + anti-σ factor NEPR
- 2oqr – MtRR Regx3
- 3sy8 – PaRR Rocr
- 4ixa – RR Saer DNA-binding domain – Staphylococcus epidermidis
- 4ml3, 4mld – SpRR Rec domain (mutant)
- 4cbv – SpRR (mutant)
- 2a9o, 2a9p, 2a9q – SpRR + Mn + BeF3
- 2pln – HP1043 – Helicobacter pylori
- 3kht – RR – Hahella chejuensis
- Response regulator complex with histidine kinase
- 3dge, 3dgf – TmRR + sensor protein
- 3a0r – TmTrrA (mutant) + sensor protein
- 4jas, 4jav – TmRR (mutant) + histidine kinase
- ↑ Smith JG, Latiolais JA, Guanga GP, Citineni S, Silversmith RE, Bourret RB. Investigation of the role of electrostatic charge in activation of the Escherichia coli response regulator CheY. J Bacteriol. 2003 Nov;185(21):6385-91. PMID:14563873
- ↑ Ladds JC, Muchova K, Blaskovic D, Lewis RJ, Brannigan JA, Wilkinson AJ, Barak I. The response regulator Spo0A from Bacillus subtilis is efficiently phosphorylated in Escherichia coli. FEMS Microbiol Lett. 2003 Jun 27;223(2):153-7. PMID:12829280
- ↑ Hecht GB, Newton A. Identification of a novel response regulator required for the swarmer-to-stalked-cell transition in Caulobacter crescentus. J Bacteriol. 1995 Nov;177(21):6223-9. PMID:7592388
- ↑ Hecht GB, Newton A. Identification of a novel response regulator required for the swarmer-to-stalked-cell transition in Caulobacter crescentus. J Bacteriol. 1995 Nov;177(21):6223-9. PMID:7592388
