Matriptase: Difference between revisions
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== Function == | == Function == | ||
'''Matriptase''' or '''suppressor of tumorigenicity 14 protein''' (ST14) is an epithelial-derived, membrane multi-domain serine protease. ST14 cleaves and activates hepatocyte | '''Matriptase''' or '''suppressor of tumorigenicity 14 protein''' (ST14) is an epithelial-derived, membrane multi-domain serine protease. ST14 cleaves and activates hepatocyte growth factor/scatter factor and urokinase plasminogen. Benzamidine is an inhibitor of ST14. ST14 catalytic domain contains residues 615-855<ref>PMID:16838070</ref>. | ||
== Relevance == | == Relevance == | ||
ST14 is a target for anti-cancer therapy. | ST14 has a role in ovarian cancer and is a target for anti-cancer therapy<ref>PMID:12779007</ref>. Inflammation-associated reactive oxygen species and tissue acidity enhance ST14 activation in some skin diseases<ref>PMID:21123732</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
ST14 active site has the conformation of a typical serine protease like trypsin or chymotrypsin with the Ser-His-Asp catalytic triad and Gly-Ser oxyanion hole. The inhibitor benzamidine blocks the | ST14 active site has the conformation of a typical serine protease like trypsin or chymotrypsin with the Ser-His-Asp catalytic triad and Gly-Ser oxyanion hole. The inhibitor benzamidine blocks the catalytic triad<ref>PMID:11696548</ref>. | ||
</StructureSection> | </StructureSection> | ||
