5j6x: Difference between revisions
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==Crystal structure of the apo-Zalpha of Zebrafish PKZ== | |||
<StructureSection load='5j6x' size='340' side='right' caption='[[5j6x]], [[Resolution|resolution]] 2.49Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5j6x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J6X FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j6x OCA], [http://pdbe.org/5j6x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j6x RCSB], [http://www.ebi.ac.uk/pdbsum/5j6x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j6x ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The Z-DNA-binding domain of PKZ from zebrafish (Danio rerio; drZalphaPKZ ) contains the largest beta-wing among known Z-DNA-binding domains. To elucidate the functional implication of the beta-wing, we solved the crystal structure of apo-drZalphaPKZ . Structural comparison with its Z-DNA-bound form revealed a large conformational change within the beta-wing during Z-DNA binding. Biochemical studies of protein mutants revealed that two basic residues in the beta-wing are responsible for Z-DNA recognition as well as fast B-Z transition. Therefore, the extra basic residues in the beta-wing of drZalphaPKZ are necessary for the fast B-Z transition activity. | |||
Structural and functional studies of a large winged Z-DNA-binding domain of Danio rerio protein kinase PKZ.,Subramani VK, Kim D, Yun K, Kim KK FEBS Lett. 2016 Jul;590(14):2275-85. doi: 10.1002/1873-3468.12238. Epub 2016 Jun , 23. PMID:27265117<ref>PMID:27265117</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 5j6x" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Kim, D]] | |||
[[Category: Kim, K K]] | |||
[[Category: Subramani, V K]] | |||
[[Category: Dna binding protein]] | |||
[[Category: Pkz zdna zalpha whth]] | |||
Revision as of 21:08, 10 September 2016
Crystal structure of the apo-Zalpha of Zebrafish PKZ
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