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==Structure of the N254Y/H258Y double mutant of the Phosphatidylinositol-Specific Phospholipase C from S.aureus==
==Structure of the N254Y/H258Y double mutant of the Phosphatidylinositol-Specific Phospholipase C from S.aureus==
<StructureSection load='4f2u' size='340' side='right' caption='[[4f2u]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
<StructureSection load='4f2u' size='340' side='right'caption='[[4f2u]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4f2u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staae Staae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F2U FirstGlance]. <br>
<table><tr><td colspan='2'>[[4f2u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_str._Newman Staphylococcus aureus subsp. aureus str. Newman]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F2U FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v16|3v16]], [[3v18|3v18]], [[3v1h|3v1h]], [[4f2b|4f2b]], [[4f2t|4f2t]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f2u OCA], [https://pdbe.org/4f2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f2u RCSB], [https://www.ebi.ac.uk/pdbsum/4f2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f2u ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">plc, NWMN_0041 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=426430 STAAE])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_diacylglycerol-lyase Phosphatidylinositol diacylglycerol-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.13 4.6.1.13] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f2u OCA], [http://pdbe.org/4f2u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4f2u RCSB], [http://www.ebi.ac.uk/pdbsum/4f2u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4f2u ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE]] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.  
[https://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Phosphatidylinositol diacylglycerol-lyase]]
[[Category: Large Structures]]
[[Category: Staae]]
[[Category: Staphylococcus aureus subsp. aureus str. Newman]]
[[Category: Cheng, J]]
[[Category: Cheng J]]
[[Category: Gershenson, A]]
[[Category: Gershenson A]]
[[Category: Goldstein, R]]
[[Category: Goldstein R]]
[[Category: Roberts, M F]]
[[Category: Roberts MF]]
[[Category: Stec, B]]
[[Category: Stec B]]
[[Category: Alpha beta barrel]]
[[Category: Lyase]]
[[Category: Membrane interface]]
[[Category: Phosphatidylinositol-specific phospholipase c]]

Revision as of 04:30, 7 October 2022

Structure of the N254Y/H258Y double mutant of the Phosphatidylinositol-Specific Phospholipase C from S.aureus

4f2u, resolution 2.19Å

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