Semaphorin: Difference between revisions
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<StructureSection load='3nvn' size='450' side='right' scene='' caption='Glycosylated human semaphorin 7A ( | <StructureSection load='3nvn' size='450' side='right' scene='46/466531/Cv/2' caption='Glycosylated human semaphorin 7A (deeppink) complex with plexin-C1 (cyan) and Ca+2 ion (green), [[3nvn]]'> | ||
== Function == | == Function == | ||
'''Semaphorin''' (SEMA) are membrane proteins which act as axonal growth guidance molecules. SEMA act as short-range inhibitory signal<ref>PMID:10934324</ref>. SEMA and Plexin are crucial for the development and homeostasis of nervous, immune and cardiovascular systems. There are 8 classes of SEMA numbered 1 to 7 and V (viral). Each class has several subgroups which share similar characteristics. | '''Semaphorin''' (SEMA) are membrane proteins which act as axonal growth guidance molecules. SEMA act as short-range inhibitory signal<ref>PMID:10934324</ref>. SEMA and Plexin are crucial for the development and homeostasis of nervous, immune and cardiovascular systems. There are 8 classes of SEMA numbered 1 to 7 and V (viral). Each class has several subgroups which share similar characteristics. | ||
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== Structural insights == | == Structural insights == | ||
SEMA interacts with plexin C1 via 3 regions: SEMA extrusion helix, loop4c-4d and blade 3<ref>PMID:20727575</ref>. | SEMA interacts with plexin C1 via 3 regions: <scene name='46/466531/Cv/1'>SEMA extrusion helix</scene>, <scene name='46/466531/Cv/3'>loop4c-4d</scene> and <scene name='46/466531/Cv/4'>blade 3</scene><ref>PMID:20727575</ref>. Water molecules shown as red spheres. | ||
</StructureSection> | </StructureSection> | ||
==3D structures of semaphorin== | ==3D structures of semaphorin== | ||
