Siderocalin: Difference between revisions
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<StructureSection load='1x89' size='450' side='right' caption='Human siderocalin complex with the siderophore carboxymycobactin (PDB code [[1x89]])' scene='48/488406/Cv/1' > | <StructureSection load='1x89' size='450' side='right' caption='Human siderocalin complex with the siderophore carboxymycobactin (PDB code [[1x89]])' scene='48/488406/Cv/1' > | ||
== Function == | == Function == | ||
'''Siderocalin''' (Scn) binds ferric siderophores in order to intercept delivery of iron to bacteria which require it thus impeding their virulence<ref>PMID:19053425</ref>. | '''Siderocalin''' (Scn) or '''neutrophil gelatinase-associated lipocalin''' binds ferric siderophores in order to intercept delivery of iron to bacteria which require it thus impeding their virulence<ref>PMID:19053425</ref>. | ||
== Relevance == | == Relevance == | ||
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*Siderocalin or lipocalin-2 | *Siderocalin or lipocalin-2 | ||
**[[5jr8]], [[3bx8]] – hScn NGAL - human<br /> | **[[5jr8]], [[3bx8]], [[5khp]], [[5kid]], [[5kic]] – hScn NGAL - human<br /> | ||
**[[3s26]] – mScn NGAL - mouse<br /> | **[[3s26]] – mScn NGAL - mouse<br /> | ||
**[[2kt4]] – qScn Q83 – quail<br /> | **[[2kt4]] – qScn Q83 – quail<br /> | ||
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*Siderocalin complex | *Siderocalin complex | ||
**[[4mvi]], [[4mvk]], [[4mvl]] – hScn NGAL (mutant) + | **[[4mvi]], [[4mvk]], [[4mvl]] – hScn NGAL (mutant) + β-amyloid protein 40 peptide<br /> | ||
**[[3bx7]] – hScn NGAL + CTLA-4<br /> | **[[3bx7]] – hScn NGAL + CTLA-4<br /> | ||
**[[3tzs]] – hScn NGAL (mutant) + phenylurea<br /> | **[[3tzs]] – hScn NGAL (mutant) + phenylurea<br /> | ||
