5nip: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5nip is ~~ON HOLD~~

==An i-motif containing the neutral cytidine protonated analogue pseudoisocytidine==

== Structural highlights ==

<table><tr><td colspan='2'>[[5nip]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NIP FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=8YN:'>8YN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nip OCA], [http://pdbe.org/5nip PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nip RCSB], [http://www.ebi.ac.uk/pdbsum/5nip PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nip ProSAT]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Incorporation of pseudoisocytidine (psC), a neutral analogue of protonated cytidine, in i-motifs has been studied by spectroscopic methods. Our results show that neutral psC:C base pairs can stabilize i-motifs at neutral pH, but the stabilization only occurs when psC:C base pairs are located at the ends of intercalated C:C+ stacks. When psC occupies central positions, the resulting i-motifs are only observed at low pH and psC:C+ or psC:psC+ hemiprotonated base pairs are formed instead of their neutral analogs. Overall, our results suggest that positively charged base pairs are necessary to stabilize this non-canonical DNA structure.

~~Authors:~~ Mir, B., Soles, X., Gonzalez, C., Escaja, N.

The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures.,Mir B, Soles X, Gonzalez C, Escaja N Sci Rep. 2017 Jun 5;7(1):2772. doi: 10.1038/s41598-017-02723-y. PMID:28584239<ref>PMID:28584239</ref>

~~Description~~: ~~An i-motif containing the neutral cytidine protonated analogue pseudoisocytidine~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

[[Category: ~~Unreleased Structures~~]]

</div>

== References ==

__TOC__

</StructureSection>

[[Category: Escaja, N]]

[[Category: Gonzalez, C]]

[[Category: Mir, B]]

~~[[Category: Gonzalez, C]]~~

[[Category: Soles, X]]

[[Category: ~~Escaja, N~~]]

[[Category: Dna]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5nip is ON HOLD
+==An i-motif containing the neutral cytidine protonated analogue pseudoisocytidine==
+<StructureSection load='5nip' size='340' side='right' caption='[[5nip]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5nip]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NIP FirstGlance]. <br>
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=8YN:'>8YN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nip OCA], [http://pdbe.org/5nip PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nip RCSB], [http://www.ebi.ac.uk/pdbsum/5nip PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nip ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Incorporation of pseudoisocytidine (psC), a neutral analogue of protonated cytidine, in i-motifs has been studied by spectroscopic methods. Our results show that neutral psC:C base pairs can stabilize i-motifs at neutral pH, but the stabilization only occurs when psC:C base pairs are located at the ends of intercalated C:C+ stacks. When psC occupies central positions, the resulting i-motifs are only observed at low pH and psC:C+ or psC:psC+ hemiprotonated base pairs are formed instead of their neutral analogs. Overall, our results suggest that positively charged base pairs are necessary to stabilize this non-canonical DNA structure.
-Authors: Mir, B., Soles, X., Gonzalez, C., Escaja, N.
+The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures.,Mir B, Soles X, Gonzalez C, Escaja N Sci Rep. 2017 Jun 5;7(1):2772. doi: 10.1038/s41598-017-02723-y. PMID:28584239<ref>PMID:28584239</ref>
-Description: An i-motif containing the neutral cytidine protonated analogue pseudoisocytidine
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 5nip" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Escaja, N]]
+[[Category: Gonzalez, C]]
 [[Category: Mir, B]]
-[[Category: Gonzalez, C]]
 [[Category: Soles, X]]
-[[Category: Escaja, N]]
+[[Category: Dna]]