Single-stranded DNA-binding protein

spinqualitylabelsall models E. coli SSB complex with ssDNA (stick model) and UMP 1eqq Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Single-stranded DNA-binding protein (SSB) binds to single-stranded regions of DNA (ssDNA) to protect it from annealing, prevention of secondary structure formation and digestion. SSB binds to DNA in a sequence-independent manner. The binding of SSB enables processes like replication, DNA repair and recombination to occur. SSB can form complexes with specific genome maintenance proteins helping their activities. Viral SSB proteins are monomeric. Eukaryotic SSB (Replication protein A – RPA) is a heterotrimer composed of RPA70, RPA32 and RPA14. RPA has 6 DNA-binding domains (DBD). Mitochondrial human SSB (HsmtSSB) is a homotetramer. See also Single stranded binding protein.

3D Structures of single-stranded DNA-binding protein

Updated on 20-September-2018

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• Single-stranded DNA-binding protein
  • Single stranded binding protein – SSB gp32 – Enterobacteria phage T4
    
  • 2a1k – SSB gp32 – Enterobacteria phage RB69
    
  • 1je5 – SSB – Enterobacteria phage T7
    
  • 1vqe, 1yha, 1vqb – F1SSB – Enterobacteria phage F1
    
  • 1vqa, 1vqc, 1vqd, 1vqe, 1vqf, 1vqg, 1vqh, 1vqi, 1vqj, 1ae2, 1ae3, 1gkh – F1SSB (mutant)
    
  • 2gn5 – M13SSB – Enterobacteria phage M13
    
  • 2gva, 2gvb – M13SSB (mutant) - NMR
    
  • 1adu, 1adv, 1anv, 2waz, 2wb0 – SSB C terminal – human adenovirus 5
    
  • 1urj – SSB – human herpesvirus 1
    
  • 1pfs – SSB (mutant) – Pseudomonas phage PF3 - NMR
    
  • 3ull, 1s3o, 2dud – HsmtSSB residues 16-148 – human
    
  • 1kaw – EcSSB chymotryptic domain – Escherichia coli
    
  • 1qvc, 1sru – EcSSB
    
  • 1o7i – SsSSB residues 1-119 – Sulfolobus solfataricus
    
  • 1ue1, 1ue5, 1ue7, 1ue6 – SSB – Mycobacterium tuberculosis
    
  • 1x3e, 1x3f, 1x3g, 5gqo – MsSSB – Mycobacterium smegmatis
    
  • 1se8 – DrSSB – Deinococcus radiodurans
    
  • 4exw – SSB DdrB – Deinococcus geothermalis
    
  • 1z9f – SSB – Thermotoga maritima
    
  • 2cwa – SSB – Thermus thermophilus
    
  • 2fxq, 2ihe – TaSSB – Thermus aquaticus
    
  • 2ihf – TaSSB (mutant)
    
  • 2hql – SSB – Mycoplasma pneumoniae
    
  • 3eiv – ScSSB – Streptomyces coelicolor
    
  • 4dam – ScSSB (mutant)
    
  • 3lgj, 3pgz – SSB – Bartonella henselae
    
  • 3afp, 3afq – SSB – Mycobacterium leprae
    
  • 3tqy – SSB – Coxiella burnetii
    
  • 3tek – SSB N terminal – Thermoproteus tenax
    
  • 4gs3 – SSB N terminal – Thermoanaerobacter tengcongensis
    
  • 3dm3 – SSB A domain – Methancaldococcus jannaschii
    
  • 5xgt, 5yyu – SSB N-terminal – Staphylococcus aureus
    
  • 6cqk, 6cqm, 6cqo – ySSB N terminal domain - yeast
    
  • 5m1x – ySSB N-OB domain (mutant)
    
  • 5d8e, 5d8f – hSSB residues 1-109 (mutant) - human
    
• Single-stranded DNA-binding protein complex with ssDNA
  • 1eyg – EcSSB chymotryptic domain + ssDNA
    
  • 1eqq – EcSSB + ssDNA
    
  • 2vw9 – HpSSB + ssDNA
    
  • 3vdy – SSB + ssDNA – Bacillus subtilis
    
  • 3a5u – MsSSB chymotryptic domain + ssDNA
    
  • 3udg – DrSSB + ssDNA
    
  • 2mna – SsSSB + ssDNA - NMR
    
• Other single-stranded DNA-binding protein complexes
  • 3ufm, 3uf7 – DrSSB C terminal + uracil-DNA glycosylase
    
• Replication protein A70
  • 1ewi, 2b29 - hRPA70 N terminal - NMR
    
  • 4ipc, 4ipd, 4ipg - hRPA70 N terminal (mutant)
    
  • 1fgu – hRPA70 central domain
    
  • 1ynx – yRPA69 DBD-A – NMR
    
  • 1jmc – hRPA70 central domain + DNA
    
  • 2b3g - hRPA70 N terminal + p53 peptide
    
  • 5eay - hRPA70 N terminal + DNA2 peptide
    
  • 4nb3, 5n85 - hRPA70 N terminal (mutant) + peptide
    
  • 5n8a - hRPA70 N terminal (mutant) + PrimPol
    
  • 4ijh, 4ijl, 4iph, 4luo, 4luv, 4luz, 4lw1, 4lwc, 4o0a, 4r4c, 4r4i, 4r4o, 4r4q, 4r4t, 5e7n - hRPA70 N terminal (mutant) + inhibitor
    
• Replication protein A70+A14+A32
  • 1l1o – hRPA14 + hRPA32 central domain + hRPA70 C terminal
    

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