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==Crystal structure of the IcmS-IcmW-DotL complex of the Legionella type IVb secretion system==
==Crystal structure of the IcmS-IcmW-DotL complex of the Legionella type IVb secretion system==
<StructureSection load='5xnb' size='340' side='right' caption='[[5xnb]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
<StructureSection load='5xnb' size='340' side='right'caption='[[5xnb]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5xnb]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_33152 Atcc 33152]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XNB FirstGlance]. <br>
<table><tr><td colspan='2'>[[5xnb]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XNB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.594&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dotL, icmO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=446 ATCC 33152]), icmS, A9P85_02475, ERS240541_02334, ERS240560_01730, ERS253249_00859, lpymg_00458, PtVF89_00590 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=446 ATCC 33152]), icmW ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=446 ATCC 33152])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xnb OCA], [http://pdbe.org/5xnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xnb RCSB], [http://www.ebi.ac.uk/pdbsum/5xnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xnb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xnb OCA], [https://pdbe.org/5xnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xnb RCSB], [https://www.ebi.ac.uk/pdbsum/5xnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xnb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DOTL_LEGPH DOTL_LEGPH] Component of the Dot/Icm type IVB secretion system (T4BSS), which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:17040490, PubMed:22694730, PubMed:32513920). Part of a subcomplex which recruits effector proteins and delivers them to the core transmembrane subcomplex (PubMed:23028312, PubMed:32513920). Plays a central role in the assembly of the subcomplex (PubMed:32513920). Required for the recruitment of IcmS and IcmW to the inner membrane and for the translocation of adapter-dependent substrates (PubMed:23028312). May have ATPase activity (Probable).<ref>PMID:17040490</ref> <ref>PMID:22694730</ref> <ref>PMID:23028312</ref> <ref>PMID:32513920</ref> <ref>PMID:32513920</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 33152]]
[[Category: Large Structures]]
[[Category: Xu, D]]
[[Category: Legionella pneumophila]]
[[Category: Xu, J]]
[[Category: Xu D]]
[[Category: Zhu, Y]]
[[Category: Xu J]]
[[Category: Binding protein]]
[[Category: Zhu Y]]
[[Category: Protein binding]]
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