5v54: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5v54 ~~is ON HOLD until Paper Publication~~

==Crystal structure of 5-HT1B receptor in complex with methiothepin==

~~Authors~~: ~~Yin, W~~.C.~~, Zhou, X~~.E.~~, Yang, D~~.~~, de Waal, P~~.~~, Wang, M~~.T.~~, Dai, A~~., ~~Cai, X~~.~~, Huang, C~~.Y.~~, Liu, P~~., ~~Yin, Y~~.~~, Liu, B~~.~~, Caffrey, M~~., ~~Melcher, K~~., ~~Xu, Y~~.~~, Wang, M~~.W., ~~Xu, H~~.E., ~~Jiang, Y~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[5v54]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V54 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V54 FirstGlance]. <br>

~~Description~~: ~~Crystal structure~~ of 5-~~HT1B~~ receptor ~~in complex with methiothepin~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=89F:1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine'>89F</scene></td></tr>

~~[[Category: Unreleased Structures]]~~

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v54 OCA], [http://pdbe.org/5v54 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v54 RCSB], [http://www.ebi.ac.uk/pdbsum/5v54 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v54 ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/5HT1B_HUMAN 5HT1B_HUMAN]] This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.

__TOC__

</StructureSection>

[[Category: Caffrey, M]]

[[Category: ~~Zhou~~, X~~.E]]~~

[[Category: Cai, X]]

~~[[Category: Xu, H.E~~]]

[[Category: Dai, A]]

~~[[Category: Wang, M.T]]~~

[[Category: Huang, C Y]]

~~[[Category: Melcher, K]]~~

~~[[Category: Yin, W.C]]~~

~~[[Category: Yang, D]]~~

[[Category: Huang, C~~.Y]]~~

~~[[Category: Wang, M.W]]~~

~~[[Category: Yin,~~ Y]]

[[Category: Jiang, Y]]

[[Category: Liu, B]]

[[Category: Liu, P]]

[[Category: Melcher, K]]

[[Category: Waal, P de]]

[[Category: Wang, M T]]

[[Category: Wang, M W]]

[[Category: Xu, H E]]

[[Category: Xu, Y]]

[[Category: ~~Cai~~, X]]

[[Category: Yang, D]]

[[Category: ~~De Waal, P~~]]

[[Category: Yin, W C]]

[[Category: Yin, Y]]

[[Category: Zhou, X E]]

[[Category: 5-hydroxytryptamine]]

[[Category: Electron transport]]

[[Category: Gpcr antagonist]]

[[Category: Ob1]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5v54 is ON HOLD  until Paper Publication
+==Crystal structure of 5-HT1B receptor in complex with methiothepin==
+<StructureSection load='5v54' size='340' side='right' caption='[[5v54]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
-Authors: Yin, W.C., Zhou, X.E., Yang, D., de Waal, P., Wang, M.T., Dai, A., Cai, X., Huang, C.Y., Liu, P., Yin, Y., Liu, B., Caffrey, M., Melcher, K., Xu, Y., Wang, M.W., Xu, H.E., Jiang, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5v54]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V54 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V54 FirstGlance]. <br>
-Description: Crystal structure of 5-HT1B receptor in complex with methiothepin
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=89F:1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine'>89F</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v54 OCA], [http://pdbe.org/5v54 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v54 RCSB], [http://www.ebi.ac.uk/pdbsum/5v54 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v54 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/5HT1B_HUMAN 5HT1B_HUMAN]] This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
+__TOC__
+</StructureSection>
 [[Category: Caffrey, M]]
-[[Category: Zhou, X.E]]
+[[Category: Cai, X]]
-[[Category: Xu, H.E]]
 [[Category: Dai, A]]
-[[Category: Wang, M.T]]
+[[Category: Huang, C Y]]
-[[Category: Melcher, K]]
-[[Category: Yin, W.C]]
-[[Category: Yang, D]]
-[[Category: Huang, C.Y]]
-[[Category: Wang, M.W]]
-[[Category: Yin, Y]]
 [[Category: Jiang, Y]]
 [[Category: Liu, B]]
 [[Category: Liu, P]]
+[[Category: Melcher, K]]
+[[Category: Waal, P de]]
+[[Category: Wang, M T]]
+[[Category: Wang, M W]]
+[[Category: Xu, H E]]
 [[Category: Xu, Y]]
-[[Category: Cai, X]]
+[[Category: Yang, D]]
-[[Category: De Waal, P]]
+[[Category: Yin, W C]]
+[[Category: Yin, Y]]
+[[Category: Zhou, X E]]
+[[Category: 5-hydroxytryptamine]]
+[[Category: Electron transport]]
+[[Category: Gpcr antagonist]]
+[[Category: Ob1]]