6fw0: Difference between revisions
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==Crystal structure of human monoamine oxidase B (MAO B) in complex with chlorophenyl-chromone-carboxamide== | ==Crystal structure of human monoamine oxidase B (MAO B) in complex with chlorophenyl-chromone-carboxamide== | ||
<StructureSection load='6fw0' size='340' side='right' caption='[[6fw0]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='6fw0' size='340' side='right'caption='[[6fw0]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6fw0]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6fw0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FW0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FW0 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene>, <scene name='pdbligand=E92:~{N}-(3-chlorophenyl)-4-oxidanylidene-chromene-3-carboxamide'>E92</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C15:N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE'>C15</scene>, <scene name='pdbligand=E92:~{N}-(3-chlorophenyl)-4-oxidanylidene-chromene-3-carboxamide'>E92</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fw0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fw0 OCA], [https://pdbe.org/6fw0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fw0 RCSB], [https://www.ebi.ac.uk/pdbsum/6fw0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fw0 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/AOFB_HUMAN AOFB_HUMAN] Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 20: | Line 19: | ||
</div> | </div> | ||
<div class="pdbe-citations 6fw0" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6fw0" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Monoamine oxidase|Monoamine oxidase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Binda | [[Category: Binda C]] | ||
[[Category: Borges | [[Category: Borges F]] | ||
[[Category: Cagide | [[Category: Cagide F]] | ||
[[Category: Manzella | [[Category: Manzella N]] | ||
[[Category: Mialet-Perez | [[Category: Mialet-Perez J]] | ||
[[Category: Parini | [[Category: Parini A]] | ||
[[Category: Reis | [[Category: Reis J]] | ||
[[Category: Uriarte | [[Category: Uriarte E]] | ||
Latest revision as of 05:14, 21 November 2024
Crystal structure of human monoamine oxidase B (MAO B) in complex with chlorophenyl-chromone-carboxamide
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