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==Structure of the PR-DUB complex==
==Structure of the PR-DUB complex==
<StructureSection load='6cga' size='340' side='right' caption='[[6cga]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='6cga' size='340' side='right'caption='[[6cga]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6cga]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CGA FirstGlance]. <br>
<table><tr><td colspan='2'>[[6cga]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CGA FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">calypso, CG8445 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), Asx, CG8787 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cga OCA], [https://pdbe.org/6cga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cga RCSB], [https://www.ebi.ac.uk/pdbsum/6cga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cga ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cga OCA], [http://pdbe.org/6cga PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cga RCSB], [http://www.ebi.ac.uk/pdbsum/6cga PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cga ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CALYP_DROME CALYP_DROME]] Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<ref>PMID:20436459</ref> [[http://www.uniprot.org/uniprot/ASX_DROME ASX_DROME]] Atypical Polycomb group protein, which may be involved in both Polycomb group (PcG) and trithorax group (trxG) complexes. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. PcG and trxG proteins act by forming multiprotein complexes, which are respectively required to maintain the transcriptionally repressive and transcriptionally active state of homeotic genes throughout development. PcG and trxG protein complexes are not required to initiate repression and activation, but to maintain it during later stages of development.<ref>PMID:20436459</ref> <ref>PMID:9477319</ref> 
[https://www.uniprot.org/uniprot/CALYP_DROME CALYP_DROME] Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<ref>PMID:20436459</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6cga" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6cga" style="background-color:#fffaf0;"></div>
==See Also==
*[[Polycomb complex proteins 3D structures|Polycomb complex proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Drome]]
[[Category: Drosophila melanogaster]]
[[Category: Ubiquitinyl hydrolase 1]]
[[Category: Large Structures]]
[[Category: Day, C L]]
[[Category: Day CL]]
[[Category: Foglizzo, M]]
[[Category: Foglizzo M]]
[[Category: Mace, P D]]
[[Category: Mace PD]]
[[Category: Middleton, A J]]
[[Category: Middleton AJ]]
[[Category: Dub complex]]
[[Category: Hetero-tetramer]]
[[Category: Hydrolase]]
[[Category: Nucleosome binding protein]]

Latest revision as of 15:04, 4 October 2023

Structure of the PR-DUB complex

6cga, resolution 3.50Å

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