6hzy: Difference between revisions
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==Crystal structure of a bacterial fucosidase with inhibitor FucPUG== | |||
<StructureSection load='6hzy' size='340' side='right' caption='[[6hzy]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6hzy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HZY FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GYZ:[(~{Z})-[(3~{S},4~{R},5~{S},6~{S})-6-methyl-3,4,5-tris(oxidanyl)oxan-2-ylidene]amino]+~{N}-phenylcarbamate'>GYZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hzy OCA], [http://pdbe.org/6hzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hzy RCSB], [http://www.ebi.ac.uk/pdbsum/6hzy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hzy ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The sugar fucose plays a myriad of roles in biological recognition. Enzymes hydrolyzing fucose from glycoconjugates, alpha-L-fucosidases, are important targets for inhibitor and probe development. Here we describe the synthesis and evaluation of novel alpha-L-fucosidase inhibitors, with X-ray crystallographic analysis using an alpha-L-fucosidase from Bacteroides thetaiotamicron helping to lay a foundation for future development of inhibitors for this important enzyme class. | |||
Synthetic and crystallographic insight into exploiting sp2-hybridization in the development of alpha-L-fucosidase inhibitors.,Coyle T, Wu L, Debowski A, Davies G, Stubbs KA Chembiochem. 2019 Jan 21. doi: 10.1002/cbic.201800710. PMID:30663832<ref>PMID:30663832</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6hzy" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Coyle, T]] | |||
[[Category: Davies, G J]] | |||
[[Category: Debowski, A W]] | |||
[[Category: Stubbs, K A]] | |||
[[Category: Wu, L]] | |||
[[Category: Hydrolase]] | |||
Revision as of 06:46, 21 February 2019
Crystal structure of a bacterial fucosidase with inhibitor FucPUG
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