Colony-stimulating factor receptor

spinqualitylabelsall models Human macrophage colony stimulating factor receptor kinase domain complex with inhibitor (PDB code 4hw7) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Colony-stimulating factor receptor (CSFR) are binding the Colony-stimulating factors and thus mediating the lineage-specific growth of cells of the mononuclear phagocytes series as bone marrow-derived precursors of monocytes and macrophages. Macrophage colony stimulating factor receptor (M-CSFR) cause the hematopoietic stem cells to differentiate into macrophages or related cell types. Granulocyte-macrophage colony stimulating factor receptor (GM-CSFR) regulates the production and activation of of hemopoietic cells as monocytes, macrophages and granulocytesparticipates in the development, survival and activation of neutrophilic granulocytes and controls dendritic cells and T-cell function. Granulocyte colony stimulating factor receptor (G-CSFR) participates in the development, survival and activation of neutrophilic granulocytes and in the development of other myeloid lineages. Disease Mutations in G-CSFR were found in patients with severe congenital neutropenia and are associated with the progression of acute myeloid leukemia. Relevance An increase in the presence of M-CSFR is observed in ovarian tumor cells. Structural highlights The kinase domain of M-CSFR interacts with a drug-designed inhibitor via the conserved kinase DFG motif and its gatekeeper threonine residue.

3D structures of colony-stimulating factor receptor

Updated on 18-November-2018

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• Macrophage colony stimulating factor 1 receptor or C-FMS; Domains: kinase 543-918; 2nd Igg-like 129-229; D1-D3 20-299; ectodomain 2-512
  • Colony-stimulating factors - hM-CSFR kinase domain - human
    
  • 5lxf – hM-CSFR residues 33-190 (mutant)
    
• M-CSFR complex
  • 2i0v, 2i0y, 2i1m, 3lco - hM-CSFR kinase domain + inhibitor
    
  • 3dpk, 3bea, 4hw7, 4r7h, 3krj, 3krl, 3lcd - hM-CSFR kinase domain (mutant) + inhibitor
    
  • 1flt, 1qty – hM-CSFR 2nd Igg-like domain + VEGF
    
  • 4wrm, 4wrl - hM-CSFR + M-CSF
    
  • 3ejj – mM-CSFR D1-D3 + M-CSF
    
  • 4exp – mM-CSFR D1-D3 + mInterleukin 34
    
  • 4dkd – hM-CSFR D1-D3 + hInterleukin 34
    
  • 4r7i – hM-CSFR kinase domain (mutant) + cancer drug
    
  • 4liq – hM-CSFR ectodomain + antibody
    
• Granulocyte-macrophage colony stimulating factor receptor
  • 4rs1 - hGM-CSFR subunit a (mutant) + GM-CSF
    
  • 4nkq - hGM-CSF CSFR subunit a (mutant) + GMCSF + cytokine receptor
    
• Granulocyte colony stimulating factor receptor or colony stimulating factor 3 receptor
  • 1gcf, 1cto - mG-CSFR C-terminal (mutant) - NMR
    
  • 2d9q - hG-CSFR Ig-CRH domain (mutant) + hG-CSF
    
  • 1pgr, 1cd9 - mG-CSFR CRH domain + hG-CSF
    

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Michal Harel, Alexander Berchansky