Fibroblast growth factor: Difference between revisions
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* '''FGF9''' is produced and secreted by the prostatic stromal cells<ref>PMID:10362017</ref>.<br /> | * '''FGF9''' is produced and secreted by the prostatic stromal cells<ref>PMID:10362017</ref>.<br /> | ||
* '''FGF10''' has essential role in the growth of fetal prostate <ref>PMID:12941620</ref>.<br /> | * '''FGF10''' has essential role in the growth of fetal prostate <ref>PMID:12941620</ref>.<br /> | ||
* '''FGF12''' is a key regulator of the vascular smooth muscle cell phenotype switch<ref>PMID:27470512</ref>.<br /> | |||
== Relevance == | == Relevance == | ||
'''FGF''' signaling is important in the pathogenesis of a variety of tumor types<ref>PMID:20094046</ref>, angiogenesis<ref>PMID:7542215</ref> and wound healing<ref>PMID:12696985</ref>. '''FGF1''' is a potentially safw candidate for restoring euglycaemia without causing a=overt adverse effects<ref>PMID:28664920</ref>. Overexpression of the high molecular weight isoform of '''FGF2''' in bone results in catabolic activity in joint cartilage and bone that leads to osteoarthropathy<ref>PMID:27732085</ref>. | '''FGF''' signaling is important in the pathogenesis of a variety of tumor types<ref>PMID:20094046</ref>, angiogenesis<ref>PMID:7542215</ref> and wound healing<ref>PMID:12696985</ref>. '''FGF1''' is a potentially safw candidate for restoring euglycaemia without causing a=overt adverse effects<ref>PMID:28664920</ref>. Overexpression of the high molecular weight isoform of '''FGF2''' in bone results in catabolic activity in joint cartilage and bone that leads to osteoarthropathy<ref>PMID:27732085</ref>. '''FGF12''' could be a therapeutic target for treating restenosis and atherosclerosis. | ||
== Structural insights == | == Structural insights == | ||
