Syntaxin-binding protein: Difference between revisions

'''Syntaxin-binding protein'''s (STXBP) are involved in the regulation of synaptic vesicle docking and fusion.  '''STXBP1''' participates in synaptic vesicle fusion via dual roles: as a docking/chaperone protein by binding [[Syntaxin]]-1 and as a fusion protein that binds SNARE complexes in a [[Syntaxin]]-1 N-peptide-dependent manner<ref name="stxbp">PMID:21193638</ref>.  '''STXBP2''' binds SNARE proteins.

Syntaxin-binding protein 1 interaction with the N-terminal peptide of syntaxin-1 which forms part of the SNARE complex shows the peptide forming a tight loop with numerous intermolecular hydrogen bonds.  The STXBP1 and the syntaxin peptide interact via numerous electrostatic and polar interactions<ref name="stxbp"/>.