6mst: Difference between revisions
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==Cryo-EM structure of human AA amyloid fibril== | |||
<StructureSection load='6mst' size='340' side='right'caption='[[6mst]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6mst]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MST OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MST FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mst OCA], [http://pdbe.org/6mst PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mst RCSB], [http://www.ebi.ac.uk/pdbsum/6mst PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mst ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Disease == | |||
[[http://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN]] Secondary amyloidosis. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN]] Major acute phase reactant. Apolipoprotein of the HDL complex. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Fandrich, M]] | |||
[[Category: Grigorieff, N]] | |||
[[Category: Liberta, F]] | |||
[[Category: Loerch, S]] | |||
[[Category: Rennegarbe, M]] | |||
[[Category: Schmidt, M]] | |||
[[Category: Aa-amyloidosis]] | |||
[[Category: Cross-beta]] | |||
[[Category: Helical]] | |||
[[Category: Protein fibril]] | |||
[[Category: Serum amyloid some]] | |||
Revision as of 12:08, 13 March 2019
Cryo-EM structure of human AA amyloid fibril
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