6j6w: Difference between revisions
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==Mutant K23N of heat shock factor 4-DBD== | |||
<StructureSection load='6j6w' size='340' side='right'caption='[[6j6w]], [[Resolution|resolution]] 1.69Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6j6w]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J6W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J6W FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j6w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j6w OCA], [http://pdbe.org/6j6w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j6w RCSB], [http://www.ebi.ac.uk/pdbsum/6j6w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j6w ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/HSF4_HUMAN HSF4_HUMAN]] Early-onset lamellar cataract;Total early-onset cataract. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/HSF4_HUMAN HSF4_HUMAN]] DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription.<ref>PMID:16371476</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Cui, L W]] | |||
[[Category: Liu, W]] | [[Category: Liu, W]] | ||
[[Category: Wang, S]] | [[Category: Wang, S]] | ||
[[Category: Xiao, Z Y]] | |||
[[Category: Transcription]] | |||
[[Category: Transcriptional factor]] | |||
Revision as of 16:06, 22 January 2020
Mutant K23N of heat shock factor 4-DBD
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